Estimation of Functional Liver Reserve Using Cholinesterases

Estimation of functional liver reserve in patients with hepatocellular carcinoma (HCC) in cirrhosis is of paramount importance to properly select candidates for surgical resection. Together with the value of bilirubin, the presence/absence of ascites and esophageal varices, and the rate of residual liver volume, which are our current parameters to measure functional liver reserve, the investigators sought to investigate the value of preoperative cholinesterases (CHE) in predict postoperative adverse outcome after hepatic resection for HCC.

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Key information

Conditions

Hepatocellular Carcinoma Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Cirrhosis Digestive System Diseases Digestive System Neoplasms Fibrosis Liver Disease Liver Diseases Liver Neoplasm Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Liver Surgery Unit, Third Department of Surgery, University of MIlan, IRCCS Istituto Clinico Humanitas

Rozzano, Milan, Milan, 20089, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Total bilirubin < 2 mg/dl
No ascites
No esophageal varices, or esophageal varices eradicated by endoscopy
Liver volume:

residual liver volume > or = 40% if total bilirubin < 1 mg/dl
residual liver volume > or = 50% if total bilirubin between 1 and 1.5 mg/dl
only limited resection if total bilirubin > 1.5 mg/dl
Portal vein embolization was selected in any case in whom RLV did not fit the previous requirements.

Exclusion criteria

Total bilirubin > 2 mg/dl
Refractory ascites
Esophageal varices

Treatment and study plan

Primary outcomes

The primary outcome was to investigate the value of preoperative cholinesterases in predict postoperative adverse outcome after hepatic resection for hepatocellular carcinoma in cirrhosis.

Sponsors and collaborators

Lead sponsor

University of Milan

Other

Registry information

Official study title

Estimation of Functional Liver Reserve in Patients With Hepatocellular Carcinoma in Cirrhosis: the Value of Preoperative Cholinesterases

Important dates

First posted: Apr 17, 2009
Registry last updated: Apr 17, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed