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Completed

NCT Number: NCT03602404

Estimating Usual Iodine Intake From Spot Urinary Iodine Concentrations

The overall objective of this study is to develop a reliable method to obtain habitual iodine intakes from spot urinary iodine concentration (UIC) and to assess the prevalence of inadequate iodine intake in school-age children and women of reproductive age. We will evaluate different methods to estimate iodine intake from UIC and estimate the prevalence of inadequate and excess iodine intake in UIC studies conducted in populations with low, adequate and high iodine intakes using the the established estimated average requirement (EAR)/Tolerable Upper Intake Level (UL) cut-point method.

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Key information

Conditions

Iodine Deficiency

Age range

9 year–13 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Papua New Guinea, Sia, Morobe Province, Papua New Guinea

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • lived in study area >= 12 months
  • no reported intake of Amiodarone
  • no history of thyroid dysfunction / goiter (past & present)
  • no exposure to iodine containing contrast agents within the last 12 months

Second arm: Women aged 18 - 49, exclusion / inclusion criteria apply, plus non-pregnant, non-lactating.

Treatment and study plan

Primary outcomes

  1. Estimated iodine intake

    Time frame: 17 months

    Estimated daily iodine intake of the study population derived from urinary iodine and creatinine concentrations measured in spot urine samples

Secondary outcomes

  1. Urinary iodine concentration

    Time frame: 17 months

    Measured in spot urine samples and 24 h urine collections

  2. Urinary creatinine concentration

    Time frame: 17 months

    Measured in spot urine samples and 24 h urine collections

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Collaborators

  • Almazov National Medical Research Centre
  • University of Papua New Guinea

Registry information

Official study title

Estimating the Usual Iodine Intake From Spot Urinary Iodine Concentrations to Obtain the Prevalence of Inadequate or Excess Iodine Intake in School-aged Children and Adults

Acronym: ITURN

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Jul 26, 2018
Registry last updated
Jun 1, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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