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Completed

NCT Number: NCT04872842

Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on 100 Regional Medical Centers in China and Population Follow-up Study

In this study, 20 regional neurosurgery centers across the country will be included, and the study cohort will be constructed on the basis of the IARP-CP cohort.The artificial intelligence platform was used to analyze the clinical, morphological, hemodynamics, aneurysm wall characteristics and other factors of unruptured aneurysms, as well as the relationship between these factors and the risk of aneurysm instability, seek the potential risk factors, and finally establish a multi-dimensional prediction model of rupture risk of intracranial aneurysms.

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Key information

Conditions

Intracranial Aneurysm Aneurysm Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Intracranial Arterial Diseases Nervous System Diseases Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-75 years old;
  • At least one unruptured intracranial aneurysm was found by CTA;
  • No relevant symptoms, receiving non-operative and conservative observation treatment;
  • Signing the informed consent.

Exclusion criteria

  • Other cerebrovascular structural lesions (such as cerebrovascular malformation and arteriovenous fistula) or craniocerebral tumors;
  • Fusiform or dissecting aneurysms;
  • Traumatic, mycotic and atrial myxoma associated aneurysms;
  • Suffering from systemic connective tissue diseases, such as polycystic kidney disease;
  • Expectant survival of no more than 3 years due to other diseases or poor general conditions;
  • Patients refuse to follow up or cannot communicate with them due to mental diseases;
  • Pregnant women or participating in other aneurysm related studies.

Treatment and study plan

Obervation

Other

This study is an observational study without any intervention

Primary outcomes

  1. Aneurysm rupture

    Time frame: 2 years

Secondary outcomes

  1. Aneurysm growth

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Beijing Tiantan Hospital

Other

Collaborators

  • Beijing Chao Yang Hospital
  • Beijing Hospital
  • Beijing Sanbo Brain Hospital
  • Beijing Tsinghua Changgeng Hospital
  • Beijing Unimed Technology Company
  • Binzhou Renmin Hospital
  • First Affiliated Hospital of Fujian Medical University
  • Fujian Medical University Union Hospital
  • Guangzhou Red Cross Hospital
  • Peking University Third Hospital
  • RenJi Hospital
  • Shanxi Provincial People's Hospital
  • Sichuan Provincial People's Hospital
  • The Affiliated Hospital of Qingdao University
  • The First Affiliated Hospital of Haerbin Medical University
  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Yan'an Affiliated Hospital of Kunming Medical University

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
May 5, 2021
Registry last updated
Nov 8, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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