Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers

Study Description:

This is a repository protocol with prospective sample collection to provide samples needed for future studies of the pathogenesis of emerging respiratory viruses. Nasal brushings will be collected from approximately 100 healthy volunteers at RML and stored in the LV to be made available for future research studies that will be conducted under separate protocols, as applicable.

Primary Objective:

To obtain nasal epithelium brushes from healthy volunteers for 1) establishment of upper respiratory tract organoids, 2) assay validation, and 3) use for research into the pathogenesis of emerging respiratory viruses.

• INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

• Aged >=18 years.
• Able to provide informed consent.
• Willing to allow biological samples and data to be stored for future research.

Exclusion criteria

An individual who meets any of the following criteria will be excluded from participation in this

study:

• History of respiratory symptoms including but not limited to runny nose, coughing, congestion, and/or fever within the past 14 days.
• NIH and laboratory staff with direct involvement in the operation or maintenance of the repository are excluded from participation.
• An individual who has any condition that, in the judgment of the investigator, may put them at undue risk or make them unsuitable for participation in the study will be excluded.