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OpenTrials
Completed

NCT Number: NCT02040181

Establishment of a Creatinine Clearance Estimation Equation and Daily Creatinine Excretion Reference Table for Taiwanese

It's important to dose according to renal function in who has impaired kidney function. There are two common methods estimating renal function: one is creatinine clearance estimated by Cockcroft-Gault (CG) equation; another is glomerular filtration rate estimated by Modification of Diet in Renal Disease (MDRD) equation.

The previous study (not published) showed that CG underestimated 24 hour measured urine creatinine clearance by our team. The difference may be due to ethnicity. Thus we want to establish a estimated creatinine clearance equation fitting in Taiwanese.

Besides, there are lots of studies discussing difference between CG and MDRD. We have found that MDRD overestimated CG in patients who were older or thin. Therefore, we want to analysis which characteristics of patients the difference are largest or smallest.

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Key information

Conditions

Estimated Creatinine Clearance

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age above or equal to 20 year-old adults
  • had 24 hour urine creatinine collection

Exclusion criteria

  • lack of at least one :sex, diagnosis, age,weight, height
  • serum creatinine beyond linear test range
  • with extreme weight or height
  • with acute kidney injury or specific diagnosis
  • with extremities of daily urine creatinine excretion

Treatment and study plan

Primary outcomes

  1. Coefficient of determination of estimated creatinine clearance equation

    Time frame: 3 years

    Compare new estimated creatinine clearance equation for Taiwanese with Cockcroft-Gault equation

Secondary outcomes

  1. Differences of daily urine creatinine excretion between Caucasian and Taiwanese

    Time frame: 3 years

Other outcomes

  1. In which subgroup that difference between CG and MDRD is smallest or largest

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jan 20, 2014
Registry last updated
Jul 30, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.