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NCT Number: NCT03299569

Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland

Acute stress-induced (Takotsubo cardiomyopathy) presents like a heart attack and is triggered by intense emotional or physical stress. Although coronary arteries are unobstructed, it has been suggested that the risk of death is similar to a myocardial infarction. The purpose of the STARR study is to identify all cases of Takotsubo in Scotland since 2010 and assess its epidemiology and outcomes.

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Key information

Conditions

Takotsubo Cardiomyopathy Cardiomyopathies Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases Ventricular Dysfunction Ventricular Dysfunction, Left

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiac Research Office

Aberdeen, Scotland, AB25 2ZD, United Kingdom

Location status: Recruiting

Location contact

Amelia Rudd, HND

CONTACT

[email protected]

01224 559573

About this study

Public Health Scotland will identify all patients centrally coded under codes I42.8 (Other cardiomyopathies), I42.9 (Cardiomyopathy, unspecified) and I51.8 (Other ill-defined heart diseases), using the Community Health Index (CHI) numbers from January 2010. All identified CHI numbers will be thereafter cross-checked with their clinical data at participating health boards to confirm a diagnosis of takotsubo cardiomyopathy and a registry of all confirmed Takotsubo cases will be established.

Clinical data will be collected for all Takotsubo patients retrospectively and prospectively. This will be compared to two contemporaneous gender and age matched control populations:

  • a cohort of randomly selected individuals from the Scottish general population supplied by Public Health Scotland
  • patients with myocardial infarction (extracted through collaboration with, the High-STEACS investigators, NCT01852123).

Electronic data linkage will be performed by Public Health Scotland to assess outcomes, prescribing and scores of prediction.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients diagnosed with Takotsubo cardiomyopathy

Exclusion criteria

  • NA

Treatment and study plan

Primary outcomes

  1. Mortality and morbidity of takotsubo syndrome

    Time frame: 13 years

    To use a nation-wide cohort (and matched national-wide control populations) to establish the all-cause mortality and consequent all cause hospitalisation rates

Secondary outcomes

  1. Specific causes of mortality and morbidity of takotsubo syndrome

    Time frame: 13 years

    To use a nation-wide cohort (and matched national-wide control populations) to establish the specific causes of mortality and morbidities requiring subsequent hospitalisation

Study contacts

Contact information is provided by the study sponsor or research team.

Amelia Rudd, HND

CONTACT

[email protected]

01224 559573

Dana Dawson, MD, MRCP

CONTACT

[email protected]

01224 437969

Sponsors and collaborators

Lead sponsor

University of Aberdeen

Other

Collaborators

  • Golden Jubilee National Hospital
  • NHS Ayrshire and Arran
  • NHS Greater Glasgow and Clyde
  • NHS Highlands
  • NHS Lanarkshire
  • NHS Lothian
  • NHS Tayside

Registry information

Official study title

Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study

Acronym: STARR

Important dates

Study start
2016
Primary completion
2028
Study completion
2028
First posted
Oct 3, 2017
Registry last updated
Mar 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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