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Completed

NCT Number: NCT01366924

Essential Amino Acids Supplementation and Muscle Protein Synthesis

The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.

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Key information

Conditions

Muscle Loss Atrophy Muscle Anabolism Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Tufts University, Boston, Massachusetts, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged 18 - 35 years
  • Weight stable
  • Recreationally active with VO2max of 40 - 50 ml/kg/min
  • Refrain from taking any NSAIDS or any aspirin-containing medications
  • Supervisor approval if a federal employee

Exclusion criteria

  • Disease or medication that affects macronutrient metabolism and/or the ability to participate in strenuous exercise
  • Allergies to foods or medications (including, but not limited to, lidocaine or phenylalanine) to be utilized in the study
  • Abnormal PT/PTT test or problems with blood clotting
  • Present condition of alcoholism or other substance abuse that compromises exercise capacity
  • Musculoskeletal injuries that compromise the ability to exercise
  • Pregnancy

Treatment and study plan

Essential Amino Acids

Dietary Supplement

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

Endurance Exercise

Other

60 minute endurance exercise session

Primary outcomes

  1. Change in muscle protein synthesis after exercise or exercise with amino acid supplementation.

    Time frame: An average change over a 210 minute recovery period from a 60 minute endurance exercise session

Secondary outcomes

  1. Change in intracellular signaling after exercise or exercise with amino acid supplementation.

    Time frame: At 30 minutes and 210 minutes after a 60 minute endurance exercise session

Sponsors and collaborators

Lead sponsor

United States Army Research Institute of Environmental Medicine

Fed

Collaborators

  • Tufts University

Registry information

Official study title

The Effect of Amino Acid Supplementation on Skeletal Muscle Protein Turnover Following Endurance Exercise

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Jun 6, 2011
Registry last updated
Jul 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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