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NCT Number: NCT07388745

ESPB vs SPSIP for Postoperative Analgesia After CABG

This prospective, randomized, active-controlled, double-blind, parallel-group study compares the postoperative analgesic efficacy and safety of ultrasound-guided bilateral Erector Spinae Plane Block (ESPB) versus bilateral Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in adult patients (45-85 years, ASA I-III) undergoing elective coronary artery bypass graft surgery. The primary outcome is postoperative pain intensity assessed by Numeric Rating Scale (NRS) at 2, 4, 8, 16, 24, and 48 hours after surgery. Secondary outcomes include intraoperative fentanyl/remifentanil consumption, postoperative morphine consumption, patient-controlled analgesia (PCA) demand/delivery parameters (if PCA is used), need for rescue analgesics, extubation and mobilization times, peak inspiratory flow measured by incentive spirometry at predefined time points, ICU and hospital length of stay, recovery quality (QoR-15 at 0, 24, and 48 hours), mortality, and block-related adverse events.

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Key information

Conditions

Coronary Arterial Disease Coronary Artery Bypass Grafting (CABG) Surgery Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Pain Management Signs and Symptoms

Age range

45 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kütahya Health Sciences University Hospital

Kütahya, 43100, Turkey (Türkiye)

Location status: Recruiting

Location contact

Merve Yaman

CONTACT

[email protected]

05363794742

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 45-85 years
  • Scheduled for elective coronary artery bypass graft (CABG) surgery
  • American Society of Anesthesiologists (ASA) I-II-III
  • Patients who provide written informed consent and agree to participate in the study

Exclusion criteria

  • Emergency cases
  • ASA IV-V
  • Known allergy to local anesthetics
  • Coagulopathy (platelet count <100,000/mm³, INR >1.5, aPTT >1.5× normal)
  • Infection at the block injection site
  • Pregnancy
  • Patients who do not provide written informed consent or decline to participate after being informed

Treatment and study plan

Ultrasound-guided Erector Spinae Plane Block (ESPB)

Procedure

Bilateral ultrasound-guided ESPB performed preoperatively under sedation at the T4-T5 transverse process level using 20 mL of 0.25% bupivacaine per side (total 40 mL).

Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB)

Procedure

Bilateral ultrasound-guided SPSIPB performed preoperatively under sedation at the 2nd-3rd intercostal space using 20 mL of 0.25% bupivacaine per side (total 40 mL).

Primary outcomes

  1. Postoperative pain intensity

    Time frame: 2, 4, 8, 16, 24, and 48 hours after surgery

    Pain intensity will be assessed using the Numerical Rating Scale (NRS), ranging from 0 to 10, where 0 = no pain and 10 = worst imaginable pain. Higher scores indicate worse pain.

Secondary outcomes

  1. Cumulative postoperative opioid consumption

    Time frame: First 24 hours after surgery

    Total opioid dose for analgesia converted to IV morphine equivalents.

  2. Need for rescue analgesia

    Time frame: Up to 48 hours after surgery

    Proportion of participants requiring rescue analgesics in addition to the standardized protocol.

  3. Quality of Recovery (QoR-15) score

    Time frame: Baseline (preoperative), postoperative 24 hours, and 48 hours after surgery

    "The Quality of Recovery-15 questionnaire (QoR-15) is a patient-reported measure consisting of 15 items. Each item is scored from 0 (unfavourable) to 10 (favourable), resulting in a total score ranging from 0 to 150. Higher total scores indicate better postoperative recovery.

Study contacts

Contact information is provided by the study sponsor or research team.

Merve Yaman, Assistant Professor

CONTACT

[email protected]

+905363794742

Sponsors and collaborators

Lead sponsor

Kutahya Health Sciences University

Other

Registry information

Official study title

A Randomized Trial Comparing Erector Spinae Plane Block Versus Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesic Efficacy in Patients Undergoing Coronary Artery Bypass Graft Surgery

Acronym: ESP-SPSIP-CABG

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 5, 2026
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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