Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06665451

Erythropoietin Gel Effect on Dental Implant Stability

* Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration. * The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically. * Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . * The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dental medicine Al-Azhar university

Asyut, Asyut Governorate, 088, Egypt

Location status: Recruiting

Location contact

Ahmed Mohsen Principle investigator

PRINCIPAL_INVESTIGATOR

Mohamed Alaa Lecturer of OMFS

CONTACT

00201091919870

Mohamed Mahjob Head of oral and maxillofacial surgery department

CONTACT

00201001544056

Mohamed Mahjob Head of oral and maxillofacial surgery department

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.
  • Good general periodontal health and maintenance.

Exclusion criteria

  • Heavy smokers who smoke more than ten cigarettes per day
  • Acute infected socket
  • Ant socket with wall defect.
  • Pregnency
  • Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.
  • Patients who had subjected to intravenous and/or oral bisphosphonate therapy.

Treatment and study plan

Non coated dental implants

Other

Patients with fresh extraction sockets in the anterior maxilla will be treated by non coated immediate implant .

Erythropoietin gel coated implants

Other

Patients with fresh extraction sockets in the anterior maxilla will be treated by immediate implant coated by erythropoietin gel.

Primary outcomes

  1. Change in implant stability

    Time frame: Baseline and after 6 month

    Implant stability will be assessed by using ( AnyCheck - Implant Stability Tester ) Utilizes physical tapping technique and dumping capacity analysis to measure implant stability with precision

Secondary outcomes

  1. Change in marginal bone level and bone density around implants

    Time frame: Baseline and after 6 month

    To evaluate the amount of marginal bone loss and bone density around osseointegrated implants, all patient will be subjected to Cone beam computed tomography (CBCT) immediate postoperative and after 6 months.

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Mohsen Principle investigator

CONTACT

[email protected]

00201020994802

Mohamed Mahjob Head of oral and maxillofacial surgery department

CONTACT

00201001544056

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Evaluation of Erythropoietin Gel Effect on Stability of Immediate Implant ( Clinical and Radiographical Study )

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Oct 30, 2024
Registry last updated
May 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.