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NCT Number: NCT07178262

Erector Spinae Block in Reducing Peri-operative Opioid Consumption in Total Abdominal Hystrectomy

Hystrectomy is a surgical procedure that involves removal of uterus from the body of patient using a lower abdominal incision. This is an extremely painful procedure which causes discomfort and greatly increases opioids consumption in the peri-operative period. This can be reduced by using nerve blocks such as Erector spinae plane block.

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Key information

Conditions

Erector Spinae Block Enhanced Recovery After Surgery (ERAS) Protocol Opioid

Age range

16 year–80 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Kulsoom Internation Hospital

Islamabad, Federal, 44000, Pakistan

Location status: Recruiting

Location contact

Nimra Member Ethics Review Committee, MBBS,FCPS

CONTACT

+92-334-5120067

About this study

Total abdominal hystrectomy is associated with significant pain due to large abdominal incision and significant surgical dissection. This greatly increases the consumption of Opioid in the peri-operative period. High dose opioid consumption is associated with constipation, nausea, vomiting and respiratory depression. This significantly hampers post operative recovery. Fascial plane blocks such as Erector spinae block provides significant analgesia greatly reducing opioid consumption and there by reducing the associated side effects.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) class: I, II and III .
  • Elective Hysterectomy under General Anesthesia.

Exclusion criteria

  • Lack of consent
  • Body mass index >35 kg/m2
  • Allergic to study medicine
  • Opioid abuse or misuse disorder
  • Chronic pain

Treatment and study plan

Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)

Drug

Bilateral Erector Spinae Block at T10 level using 30ml of 0.25% Bupivacaine will be administered under Ultrasound guidance before surgical incision.

Placebo

Drug

Bilateral Erector Spinae Block at T10 level using 30ml of Normal saline will be administered under Ultrasound guidance before surgical incision.

Primary outcomes

  1. Total Intra-operative Fentanyl consumption

    Time frame: From surgical incision till end of surgery

Secondary outcomes

  1. Total amount of IV Tramadol consumed in post operative period

    Time frame: First 24 hours after surgery

  2. Post operative pain score

    Time frame: Baseline that is pain score upon arrival in post anesthesia care unit in the post operative period and then at 1hours ,2 hours ,4 hours,6 hours,12 hours and 24 hours in the post operative period

    This will be assessed Visual Analog Scale

Study contacts

Contact information is provided by the study sponsor or research team.

Abdul Rehman, MBBS,FCPS

CONTACT

[email protected]

+92-333-5227329

Waqas Anjum, Principal Investigator, MBBS, FCPS

CONTACT

[email protected]

+92-310-3308158

Sponsors and collaborators

Lead sponsor

Kulsoom International Hospital

Other

Registry information

Official study title

Opioid Sparing Effect of Erector Spinae Block in Patients Undergoing Total Abdominal Hysterectomy; A Randomized Control Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 17, 2025
Registry last updated
Sep 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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