Epithelioid Hemangioma of Bone And Soft Tissue

The controversy surrounding epithelioid hemangioma diagnosis stems from its somewhat aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement.

The investigators reviewed the clinicopathologic and radiologic characteristics of bone and soft tissue epithelioid hemangioma in patients treated at our institution with available tissue for molecular testing.

The hypothesis is that epithelioid hemangioma may present with multifocal involvement and rare loco-regional lymph node metastasis, but it remains a benign tumor with excellent prognosis.

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Key information

Conditions

Epithelioid Hemangioma of Bone Angiolymphoid Hyperplasia with Eosinophilia Eosinophilia Epithelioid Hemangioma Granuloma Hematologic Diseases Hemic and Lymphatic Diseases Leukocyte Disorders Lymphatic Diseases Lymphoproliferative Disorders Skin Diseases Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

About this study

The investigators retrospectively reviewed patients treated for epithelioid hemangioma of the bone and soft tissue in a single insitution. The purpose of this study is to evaluate the pathological, clinical, and radiological characteristics of epithelioid hemangioma arising within bone and soft tissue, in the first cohort of cases where the definitive diagnosis is supplemented by molecular techniques.

The hypothesis is that the improved knowledge regarding this rare entity can more definitively elucidate the benign biology of epithelioid hemangioma.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with epithelioid hemangioma of bone and soft tissue in the extremities and pelvis

Exclusion criteria

patients with epithelioid hemangioma of bone and soft tissue in the spine

Treatment and study plan

Surgery

Procedure

Patients affected by epithelioid hemangioma treated with surgery

Primary outcomes

Multifocal presentation of patients with epithelioid hemangioma of bone and soft tissue without producing a fatal outcome

Time frame: 2 years

The investigators defined multifocal presentation the presence of secondary lesions by imaging at presentation of the disease or during follow-up.

Sponsors and collaborators

Lead sponsor

Istituto Ortopedico Rizzoli

Other

Registry information

Official study title

Epithelioid Hemangioma of Bone And Soft Tissue: a Benign Tumor With Metastatic Potential

Acronym: EE-META

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2017
First posted: May 30, 2017
Registry last updated: May 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed