Skip to main content
OpenTrials
Completed

NCT Number: NCT04725162

Epileptogenic Focus Localization for Children With Epilepsy Using 18F-FDG PET Molecular Imaging

This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with epilepsy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

6 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, 310009, China

About this study

This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with intractable epilepsy.

Pediatric patients with intractable epilepsy would be retrospectively included in this study. The inclusion criteria included (1) age between 6 and 18 y; (2) detailed seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/CT examination; (3) clinical diagnosis as focal epilepsy. The exclusion criteria included (a) any history of central nervous system disease; (b) poor image quality due to head movement.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 1. age between 6 and 18 years.
  • 2. detailed presurgical evaluation, including seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/Computer Tomography (CT) examination.
  • 3. clinical diagnosis as focal epilepsy.

Exclusion criteria

  • 1. any history of central nervous system (CNS) disease such as trauma and CNS tumor.
  • 2. poor image quality due to head movement.

Treatment and study plan

18F-FDG

Radiation

All subjects received 18F-FDG PET examination.

Primary outcomes

  1. Accuracy

    Time frame: Through study completion, about 6 months

    The accuracy of epilepsy focus localization.

  2. Kappa

    Time frame: Through study completion, about 6 months

    The agreement between experiment result and clinical diagnosis.

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Important dates

Study start
2014
Primary completion
2021
Study completion
2021
First posted
Jan 26, 2021
Registry last updated
Jul 12, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.