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Completed

NCT Number: NCT02067338

Epidural Low Dose Morphine in Postoperative Pain After Posterior Lumbar Spinal Surgery

The effect of epidural low-dose morphine-soaked microfibrillar collagen sponge in postoperative pain control after posterior lumbar spinal surgery: a randomized, double-blind, placebo-controlled study

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Key information

Conditions

Morphine

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Siriraj hospital

Bangkoknoi, Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 Yrs
  • Good orientation and communication

Exclusion criteria

  • opioids or sulfonamides allergy
  • Contraindication for use
  • Epidural morphine
  • Selective COX 2 inhibitor
  • Patient-controlled analgesia (PCA)
  • ASA class > 3
  • BMI ≥ 35 kg/sq.m.
  • Preoperative use of opioids within 6 Wks
  • Intraoperative bleeding > 1000ml

Treatment and study plan

1 mg morphine soak in epidural oxidized cellulose

Drug

During posterior lumbar spinal surgery , patients received 1 mg morphine-soaked in epidural oxidized cellulose.

normal saline

Drug

During posterior lumbar spinal surgery , patients received NSS -soaked in epidural oxidized cellulose.

Primary outcomes

  1. VAS measurement was recorded at twenty-four hour after posterior lumbar spinal surgery then compare VAS between low-dose 1 mg morphine-soaked microfibrillar collagen sponge method with normal saline soked

    Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

The Effect of Epidural Low-dose Morphine-soaked Microfibrillar Collagen Sponge in Postoperative Pain Control After Posterior Lumbar Spinal Surgery: a Randomized, Double-blind, Placebo-controlled

Important dates

Study start
2012
Primary completion
2013
Study completion
2014
First posted
Feb 20, 2014
Registry last updated
Feb 20, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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