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Completed

NCT Number: NCT03205540

Epidural Analgesia vs Adductor Canal Block in Bilateral TKA

This study evaluates postoperative analgesic efficacy within 48 hours between epidural analgesia and single-shot bilateral adductor canal blocks in bilateral total knee arthroplasty. Half of participants will be received continuous epidural analgesia, while other half of participants will be received single-shot bilateral adductor canal blocks.

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Key information

Conditions

Osteo Arthritis Knee

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

About this study

Continuous epidural analgesia is effective postoperative pain control but it has some limitations in patients with hypotension, concurrent anticoagulants, technical difficulty, urinary retention.

Adductor canal block is less invasive than continuous epidural analgesia. It provides effective analgesia for total knee arthroplasty and preserves quadriceps muscle strength.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged more than 18 years old undergoing bilateral total knee arthroplasty
  • American Society of Anesthesiologists physical status classification 1-3

Exclusion criteria

  • Participants deny to enroll the study
  • Allergy to bupivacaine
  • Weight less than 50 kilograms
  • Hepatic disease
  • Contraincation for neuraxial block or adductor canal block
  • Uncontrolled cardiovascular disease
  • Creatinine clearance less than 50 ml/min

Treatment and study plan

Continuous epidural block

Procedure

Continuous epidural block at level L2-3 or L3-4 with 0.0625% bupivacaine + fentanyl 2 mcg/ml infusion epidurally 5 ml/hr for 48 hours postoperatively.

Bilateral single-shot bilateral adductor canal blocks

Procedure

Bilateral single-shot adductor canal blocks, ultrasound guidance, with 0.33% bupivacaine 15 ml on each side.

Primary outcomes

  1. pain scores at rests

    Time frame: 48 hours postoperatively

    numerical rating scales

Secondary outcomes

  1. morphine consumptions

    Time frame: 48 hours postoperatively

    total miligrams of morphine use in each arm

  2. pain scores on movement

    Time frame: 48 hours postoperatively

    numerical rating scales

  3. side effects of interventions

    Time frame: 48 hours postoperatively

    nausea vomiting hypotension

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Comparison Efficacy of Analgesic Techniques: Continuous Epidural Analgesia Versus Bilateral Single-shot Adductor Canal Blocks in Patients Undergoing Bilateral Total Knee Arthroplasty

Important dates

Study start
2017
Primary completion
2021
Study completion
2021
First posted
Jul 2, 2017
Registry last updated
May 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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