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Completed

NCT Number: NCT05224570

Epidemiology of Gunshot Wounds Injuries Admitted in ICU in France

In civilian practice, the incidence of firearm violence depends on the country. In high income countries, most cases are reported in the USA or South Africa. In these countries, gunshot wounds (GSW) represent 20% of death cases in trauma centers, more than motor vehicle collisions.

The mortality in civilian practice occurs during the first 24 hours following GSW, mainly due to hemorrhage and traumatic brain injury, though long term effects on physical and psychological outcomes have also been shown.

Some factors of mortality specific to GSW have been established: multiples wounds, homicide vs suicide attempt, impact zone, or firearm caliber.

Few specific guidelines have been published concerning civilian GSW management. These cases are mostly treated in standard guidelines, such as hemorrhagic shock or traumatic brain injury guidelines. As in other trauma mechanisms, the "platinum ten minutes and golden hour" concept is applicable.

In Europe, the incidence of civilian GSW is much lower and few European studies have been published recently. Penetrating injuries in Europe are less likely to be GSW, and are more often self-inflicted than in the USA. In addition, European studies are heterogeneous, due to the difference in populations, healthcare systems and GSW being grouped with stabbing wounds under the label "penetrating trauma".

However, there is a global concern in Europe regarding a potential rise of GSW, with higher severity score than conventional trauma patients and often necessitate ICU admission. Studies analyzing data from different European countries show significantly different ICU admission rates for overall GSW, ranging from 17% up to 30%.

Therefore, the investigators conducted a multicenter, retrospective study on four French University Hospitals aiming to describe the epidemiology (mortality and type of organ damage) and identify prognosis factors of civilian GSW admitted in ICU.

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Key information

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de NIMES

Nîmes, 30029, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Admission for gunshot wound care in ICU between 1st of January 2015 and June 30th 2021 at Nimes University Hospital, Marseille North University Hospital, Montpellier University Hospital, Toulon Military Teaching Hospital.
  • Patient ≥ 15 years old

Exclusion criteria

  • Patient < 15 years old
  • Patient who objected to the use of their data.

Treatment and study plan

Primary outcomes

  1. Mortality

    Time frame: day 28

    mortality rate at day 28 of patients admitted for Gunshot wounds

Secondary outcomes

  1. Age

    Time frame: Day 0

    To identify if age is a prognosis factors of mortality of patients admitted for Gunshot

  2. Sex

    Time frame: Day 0

    To identify if sex is a prognosis factors of mortality of patients admitted for Gunshot

  3. Comorbidity

    Time frame: Day 0

    To identify if some comorbidities are some prognosis factors of mortality of patients admitted for Gunshot wounds (age, sex, comorbidity, type of gunshot, bullet impact zone, delay to reach hospital, biological parameters at ICU admission, use of antibiotics, blood transfusion, type of surgery, medical management, initiation of renal replacement therapy, length of ICU stay, ).

  4. Type of gunshot

    Time frame: Day 0

    To identify if the type of gunshot is prognosis factors of mortality of patients admitted for Gunshot wounds

  5. Bullet impact zone

    Time frame: Day 0

    To identify if the impact zone is a prognosis factors of mortality of patients admitted for Gunshot wounds

  6. Delay to reach hospital

    Time frame: Day 0

    To identify if the delay to reach hospital is a prognosis factors of mortality of patients admitted for Gunshot wounds

  7. biological parameters at ICU admission

    Time frame: Day 0

    To identify if some biological parameters at admission are prognosis factors of mortality of patients admitted for Gunshot wounds

  8. antibiotics cure

    Time frame: Day 0

    To identify if an antibiotic cure at admission is a prognosis factors of mortality of patients admitted for Gunshot wounds

  9. Blood transfusion

    Time frame: Day 0 to day 30

    To identify if a blood transfusion is a prognosis factors of mortality of patients admitted for Gunshot wounds

  10. Type of surgery

    Time frame: Day 0 to day 30

    To identify if surgery type is a prognosis factors of mortality of patients admitted for Gunshot wounds

  11. renal replacement therapy

    Time frame: Day 0 to day 30

    To identify if initiation of renal replacement therapy is a prognosis factors of mortality of patients admitted for Gunshot wounds

  12. length of ICU stay

    Time frame: Day 0 to day 30

    To identify if length of ICU stay is a prognosis factors of mortality of patients admitted for Gunshot wounds

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nīmes

Other

Registry information

Official study title

Epidemiology of Gunshot Wounds Injuries Admitted in Intensive Care Unit in France: a Retrospective Multicenter Observational Study

Acronym: GSW_in_ICU

Important dates

Study start
2015
Primary completion
2022
Study completion
2022
First posted
Feb 4, 2022
Registry last updated
Dec 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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