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NCT Number: NCT04098133

Epidemiology of Carbapenemase-producing Bacteria in a Swiss Tertiary Care Hospital

This retrospective and prospective study is to investigate the incidence of Carbapenemase-producing bacteria (CPB) at the University Hospital Basel, the time to detection of CPB and to initiation of infection control measures, the risk factors associated with carriage of CPB, type and duration of previously administrated antibiotic medication, antibiotic treatment, as well as to assess the outcomes of the affected patients.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Division of Infectious Diseases and Hospital Epidemiology

Basel, 4031, Switzerland

Location status: Recruiting

Location contact

Isabelle Vock, Dipl. med.

SUB_INVESTIGATOR

Sarah Tschudin Sutter, PD MD

CONTACT

[email protected]

+41 61 328 68 10

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with detection of carbapenemase-producing bacteria from January 1st , 2008 until December 31st , 2028

Exclusion criteria

  • Patients with documented refusal of subsequent use of their data

Treatment and study plan

data collection for demographic data

Other

data collection for demographic data (age, gender, hospital admission and discharge date, length of stay, hospitalization prior to current hospital stay (acute care facilities, long-term healthcare centres, nursing homes), discharge destination, outcome, cause of death, travel history, previous exposure to antibiotics and proton pump Inhibitors)

data collection for clinical data

Other

data collection for clinical data (comorbidities, Charlson Comorbidity Index, immunosuppressive treatment, date of diagnosis of CPB, days between hospital admission and diagnosis of CPB, type of consecutive infection, indwelling vascular hardware, urinary catheterization, surgical therapies)

data collection for treatment data

Other

data collection for treatment data (antibiotic therapy, immunosuppressive therapy, concomitant medication)

data collection for microbiological data

Other

data collection for microbiological data (species of CPB, type of sample, date of sample, history of colonization or infection with any antibiotic resistant pathogen)

Primary outcomes

  1. incidence of CPB at the University Hospital Basel (number)

    Time frame: from January 1st , 2008 until December 31st, 2028

    incidence of CPB at the University Hospital Basel (number)

Secondary outcomes

  1. time to detection of CPB (days)

    Time frame: from January 1st , 2008 until December 31st, 2028

    time to detection of CPB (days)

  2. time to initiation of infection control measures

    Time frame: from January 1st , 2008 until December 31st, 2028

    time to initiation of infection control measures

  3. time to adequate treatment in patients with CPB infections

    Time frame: from January 1st , 2008 until December 31st, 2028

    time to adequate treatment in patients with CPB infections

  4. presence of established risk factors for CPB

    Time frame: from January 1st , 2008 until December 31st, 2028

    presence of established risk factors for CPB

  5. length of hospital stay (days)

    Time frame: from January 1st , 2008 until December 31st, 2028

    length of hospital stay (days)

  6. discharge destination

    Time frame: from January 1st , 2008 until December 31st, 2028

    discharge destination

  7. cure from infection

    Time frame: from January 1st , 2008 until December 31st, 2028

    cure from infection

  8. cause-specific mortality (number)

    Time frame: from January 1st , 2008 until December 31st, 2028

    cause-specific mortality (number)

  9. all-cause mortality (number)

    Time frame: from January 1st , 2008 until December 31st, 2028

    all-cause mortality (number)

Study contacts

Contact information is provided by the study sponsor or research team.

Isabelle Vock, Dipl. med

CONTACT

[email protected]

Sarah Tschudin Sutter, Prof. Dr. MD

CONTACT

[email protected]

+41 61 328 68 10

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Acronym: CPB-Epi Basel

Important dates

Study start
2019
Primary completion
2029
Study completion
2029
First posted
Sep 23, 2019
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.