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Completed

NCT Number: NCT05236283

Epidemiology of Bacteremia at Two Tertiary ICUs in Switzerland

The objectives of the retrospective cohort study is to describe the actual current practice of antibiotic treatment duration for bloodstream infections in critically ill patients at two tertiary hospitals (ICU Inselspital Bern and ICU CHUV Lausanne), to examine patient, pathogen and infectious syndrome factors associated with selection of shortened treatment duration, and to describe the expected time course of clinical resolution among bacteremic patients.

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Key information

Conditions

Bacteremia Bacterial Infections Bacterial Infections and Mycoses Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Departement of Intensive Care Medicine

Bern, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient has a positive blood culture with a pathogenic organism Patient is critically ill at the time the blood culture was collected as defined by the following:

  • was treated at the ICU/IMC at the time of blood culture collection;
  • or has been admitted to ICU/IMC in the 48 hours after blood culture collection

Exclusion criteria

  • Patient has a single positive blood culture with a common contaminant organism:
  • coagulase negative staphylococci;
  • Bacillus spp.;
  • Corynebacterium spp.;
  • Propionibacterium spp.;
  • Aerococcus spp.;
  • Micrococcus spp.
  • Explicit documentation that the patient does not want to participate in any study

Treatment and study plan

Blood culture

Diagnostic Test

Blood Culture

Primary outcomes

  1. Antibiotic Treatment Duration

    Time frame: Hospital discharge, expected to be on average ca. 15-20 days

    Days of adequate antibiotic treatment in Patients with Bacteremia

Secondary outcomes

  1. Days of ICU stay

    Time frame: ICU discharge, expected to be on average ca. 5-15 days

    Days of ICU Stay in Patients with Bacteremia

  2. Days of hospital stay

    Time frame: Hospital discharge, expected to be on average ca. 15-25 days

    Days of Inhospital Stay in Patients with Bacteremia

Sponsors and collaborators

Lead sponsor

Insel Gruppe AG, University Hospital Bern

Other

Registry information

Official study title

Duration of Antimicrobial Treatment for Bloodstream Infections in Swiss Critically Ill Patients - Retrospective Double Center Study

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Feb 11, 2022
Registry last updated
Jan 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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