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NCT Number: NCT00215280

Epidemiology and Control of Mansonella Perstans Infection in Uganda

Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.

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Key information

Conditions

Mansonelliasis Abdominal Pain Abdominal Pains Dipetalonema Infections Filariasis Helminthiasis Hemic and Lymphatic Diseases Infections Lymphatic Diseases Lymphedema Lymphoedema Nematode Infections Neurologic Manifestations Pain Parasitic Diseases Pathological Conditions, Signs and Symptoms Pruritus Secernentea Infections Signs and Symptoms Signs and Symptoms, Digestive Skin Diseases Skin Manifestations Skin and Connective Tissue Diseases Spirurida Infections

Age range

5 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Luwero

Luwero and Mukono, Luwero and Mukono Districts, Uganda

About this study

Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M. perstans in Uganda with relevance to control

Specific objectives:

  • To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
  • To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
  • To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals >= 5 years with or without M. perstans infection

Exclusion criteria

  • Individuals < 5 years
  • Pregnant women

Treatment and study plan

ivermectin and albendazole

Drug

Primary outcomes

  1. microfilariae periodicity patterns

  2. epidemiology of M. perstans at community level

  3. clinical spectre among infected

  4. reduction in microfilaraemia

Secondary outcomes

  1. treatment effect on clinical manifestations

Sponsors and collaborators

Lead sponsor

DBL -Institute for Health Research and Development

Other

Collaborators

  • Ministry of Health, Uganda

Registry information

Official study title

Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda

Important dates

Study start
2005
Study completion
2006
First posted
Sep 22, 2005
Registry last updated
Apr 20, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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