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NCT Number: NCT05380570

Epidemiological Study of Korean Radiation Workers

Health risks of radiation exposure in the moderate-to-high dose range have been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. The purpose of this study is to construct a cohort of Korean radiation workers and to assess health effects associated with occupational radiation exposure. The study population is expected to be about 190,000 Korean radiation workers who have been registered with the Nuclear Safety and Security Commission since 1984. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data are collected based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Occupational Exposure to Radiation Hematologic Diseases Hemic and Lymphatic Diseases Leukemia Leukemia, Radiation-Induced Neoplasms Neoplasms by Histologic Type Neoplasms, Radiation-Induced Radiation Effects Radiation Injuries Wounds and Injuries

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Korea Institute of Radiological & Medical Sciences

Seoul, Nowon-gu, 01812, South Korea

About this study

The study population of this study is approximately 190000 Korean radiation workers registered with the Nuclear Safety and Security Commission since 1984. Diagnostic medical radiation workers were not included in the study population. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data for radiation workers are collected retrospectively or prospectively based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases. This data collection will be continued at 5-year intervals to update information on existing study participants and recruit newly hired workers if possible.

Age- and sex-specific standardized incidence and mortality ratios will be calculated for overall comparisons of cancer and non-cancer disease risks with general population. For dose-response assessment, excess relative risk (per Gy) and excess absolute risk (per Gy) will be estimated with adjustments for age and potential confounders, such as lifestyle factors and socioeconomic status.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Korean radiation workers in the national dose registry (except for diagnostic medical radiation workers)

Exclusion criteria

  • Unidentified personal identification numbers
  • Foreigner

Treatment and study plan

Occupational radiation exposure

Radiation

Ionizing radiation in workplaces

Primary outcomes

  1. Radiation-induced cancer risk

    Time frame: year 4

    Cancer risk associated with occupational radiation exposure

  2. Radiation-induced cancer risk

    Time frame: year 9

    Cancer risk associated with occupational radiation exposure

Secondary outcomes

  1. Radiation-induced non-cancer risk

    Time frame: year 4

    Non-cancer disease risk associated with occupational radiation exposure

  2. Radiation-induced non-cancer risk

    Time frame: year 9

    Non-cancer disease risk associated with occupational radiation exposure

Sponsors and collaborators

Lead sponsor

Korea Institute of Radiological & Medical Sciences

Other Gov

Registry information

Official study title

Health Effects Associated With Occupational Radiation Exposure Among Korean Radiation Workers (Korean Radiation Workers Study)

Acronym: KRWS

Important dates

Study start
2021
Primary completion
2022
Study completion
2031
First posted
May 19, 2022
Registry last updated
Apr 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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