Recruiting

NCT Number: NCT07604610

Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations

Visceral obesity is a well-established risk factor for the development of chronic non-communicable diseases (NCDs). Epicardial fat tissue (EFT) is located on the surface of the myocardium and may directly affect cardiac function and contribute to structural and functional remodeling.

According to the literature, increased EFT thickness is associated with a wide range of NCDs, disease severity, and prognosis.

The aim of this study is to investigate the associations between EFT thickness and clinical and anamnestic parameters, as well as to evaluate the prognostic value of this parameter in patients aged 50-70 years from the Russian Federation, Kazakhstan, Uzbekistan, and Kyrgyzstan.

Recruiting

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Key information

Conditions

Epicardial Fat Tissue (EFT) Body Weight Chronic Non-Communicable Diseases (NCDs) Disease Attributes Metabolic Diseases Noncommunicable Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Abdominal Overnutrition Overweight Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Visceral Obesity

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Medical Research Center for Therapy and Preventive Medicine

Moscow, Russia

Location status: Recruiting

Location contact

Olga Dzhioeva, MD, Associate Professor

CONTACT

[email protected]

+79166141821

About this study

The study is designed to:

Assess physical examination findings, laboratory parameters, and comorbidities;
Evaluate transthoracic echocardiography parameters;
Analyze associations between EFT thickness and clinical and anamnestic characteristics;
Determine threshold values of EFT thickness associated with structural and functional myocardial remodeling;
Conduct follow-up via telephone to assess study endpoints;
Evaluate the prognostic value of EFT thickness with respect to a composite endpoint.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 50-70 years undergoing transthoracic echocardiography in inpatient or outpatient settings;
Ability and willingness to provide informed consent.

Exclusion criteria

Refusal to sign informed consent;
Inability to perform transthoracic echocardiography or poor image quality;
Severe psychiatric disorders.

Treatment and study plan

Primary outcomes

Composite endpoint - all-cause mortality - hospitalizations - major adverse cardiovascular events (MACE)

Time frame: 12 months

Study contacts

Contact information is provided by the study sponsor or research team.

Elizaveta Rogozhkina, PhD

CONTACT

[email protected]

+79371047331

Olga Dzhioeva, MD, Associate Professor

CONTACT

[email protected]

+79166141821

Sponsors and collaborators

Lead sponsor

National Medical Research Center for Therapy and Preventive Medicine

Other Gov

Registry information

Official study title

Epicardial Fat Tissue Assessed by Echocardiography in Russian and Asian Populations: Association With Chronic Non-Communicable Diseases and Risk Factors

Acronym: EPIGRAPH

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2028
First posted: May 22, 2026
Registry last updated: May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed