Entecavir Prophylaxis for Hepatitis B Reactivation for CD20 Positive B-cell Lymphoma Patients With Resolved Hepatitis B (Negative Hepatitis B Surface Antigen, Positive Hepatitis B Core Antibody)

Inclusion criteria

• Histopathologically confirmed CD20 positive B-cell lymphoma;
• Plan to receive first-line anti-lymphoma therapy containing CD20 monoclonal antibodies;
• Negative HBsAg, HBV-DNA lower than the detection limit and positive anti-HBC at baseline;
• Total bilirubin less than 1.5X the upper limit of normal (ULN), AST and ALT less than 2.5X ULN;
• ECOG PS: 0~2;
• Estimated survival time >3 months.

Exclusion criteria

• Positive HBsAg or HBV-DNA higher than the detection limit at baseline;
• Previous chemotherapy or radiotherapy for lymphoma;
• Other primary liver diseases, such as chronic hepatitis C, hepatitis D, autoimmune hepatitis, Wilson' s disease or primary biliary cirrhosis;
• Pregnant or lactating women;
• History of immunodeficiency, including positive HIV, or other acquired congenital immunodeficiency disease, or history of organ transplantation.