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Completed

NCT Number: NCT00192855

Entacapone Augmentation for Schizophrenia

This study is testing the hypothesis that Entacapone added to ongoing antipsychotic treatment can be beneficial in schizophrenic patients with negative symptoms.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rambam medical center

Haifa, 31096, Israel

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • predominantly negative symptoms
  • stable on ongoing antipsychotic treatment

Exclusion criteria

  • acute psychotic exacerbation
  • suicidal ideation
  • uncontrolled systemic disease

Treatment and study plan

Entacapone

Drug

Entacapone 600mg BID

Primary outcomes

  1. Improvement in specific rating scales during the study and after completion, compared to baseline.

    Time frame: Baseline and once a month untill end of study

Secondary outcomes

  1. Change in PANSS score.

    Time frame: Before and after intervention

Sponsors and collaborators

Lead sponsor

Rambam Health Care Campus

Other

Registry information

Official study title

Entacapone Augmentation for Schizophrenia- A Randomized Controlled Trial

Important dates

Study start
2003
Primary completion
2006
Study completion
2006
First posted
Sep 19, 2005
Registry last updated
Aug 25, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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