Enhancing Utility of Neuropsychological Evaluation for Earlier and Effective Diagnosis of Dementia in Parkinson's Disease

Dementia is observed in 80% of people living with advanced stage Parkinson's disease, however, there are inadequate opportunities for early and effective diagnosis of dementia in current clinical practice. This study aims to identify whether a new tool called PDCogniCare, can improve detection of dementia in people living with Parkinson's disease, and to explore what factors might influence its use in healthcare services.

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Key information

Conditions

Dementia (Diagnosis) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dementia Disease Mental Disorders Movement Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Parkinson Disease Parkinson Disease (PD) Parkinson Disease Dementia (PDD) Parkinsonian Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The PDCogniCare tool integrates best practice guidelines for cognitive evaluations in people living with Parkinson's disease, along with a tailored digital platform to support guideline implementation and routinely track cognitive changes throughout the disease course. We hypothesize that PDCogniCare will significantly enhance cognitive evaluations within healthcare services. Embedded process and economics evaluations will inform implementation and sustainable business models of PDCogniCare.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

People living with idiopathic Parkinson's disease, one year or more post-diagnosis, attending Movement Disorder Clinics

Exclusion criteria

People with severe Parkinson's disease who aren't able to communicate
People with comorbid neurological conditions (e.g. Stroke)

Treatment and study plan

PDCogniCare platform

Other

Digital platform designed to support early and accurate detection of dementia in people living with Parkinson's disease

Primary outcomes

Change in percentage of people with Parkinson's disease diagnosed with dementia

Time frame: 12 months from enrolment

Secondary outcomes

Change in percentage of people with Parkinson's disease diagnosed with mild cognitive impairment

Time frame: 12 months from enrolment

Study contacts

Contact information is provided by the study sponsor or research team.

Nadeeka Dissanayaka

CONTACT

[email protected]

+617 3346 5577

Tiffany Au

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

The University of Queensland

Other

Collaborators

Australian Dementia Network
Dementia Australia
Lions Club of Brisbane Inner North
Medical Research Future Fund
Metro North Health
Metro South Health
OPN365
Parkinson's Queensland
Queensland University of Technology
University of Sydney

Registry information

Acronym: PDCogniCare

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Aug 11, 2025
Registry last updated: Aug 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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