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Completed

NCT Number: NCT07008313

Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation in Perioperative Period

The enhanced recovery after surgery(ERAS) has been gradually extended from its initial colorectal surgery to almost all surgical fields. However, there are few reports about the application value of ERAS in emergency surgery. The goal of this clinical trial is to evaluate the value of ERAS in the perioperative period of acute gastrointestinal perforation. All the patients will be treated by emergency operation. The changes of CRP, PA, PCT in Plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.

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Key information

Conditions

Acute Gastrointestinal Perforation Enhanced Recovery After Surgery

Age range

14 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

the Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age≥14years old and ≤80 years old
  • The initial diagnosis is acute gastrointestinal perforation

Exclusion criteria

  • Patients with unconsciousness,or patients with past psychiatric history
  • Patients with shock and/or severe organ failure
  • Patients who are pregnant
  • Patients with severe spinal deformity who are unable to receive epidural anesthesia

Treatment and study plan

The enhanced recovery after surgery

Behavioral

Enhanced recovery after surgery (ERAS) refers to a series of optimal management measures which are proved to be effective by evidence-based medical evidence in order to reduce patients' psychological and physiological traumatic stress reaction

Traditional treatment methods.

Behavioral

Traditional treatment methods.

Primary outcomes

  1. change of the c-reactive protein in plasma

    Time frame: 1, 3, and 7 days after surgery

  2. change of the prealbumin in plasma

    Time frame: 1, 3, and 7 days after surgery

  3. change of the procalcitonin in plasma

    Time frame: 1, 3, and 7 days after surgery

Sponsors and collaborators

Lead sponsor

Hebei Medical University

Other

Registry information

Official study title

Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation, a Randomized Controlled Study

Important dates

Study start
2018
Primary completion
2023
Study completion
2023
First posted
Jun 6, 2025
Registry last updated
Jun 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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