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NCT Number: NCT07564063

Enhanced Recovery After Surgery in Hysterectomy Patients

This prospective randomized controlled clinical trial aims to evaluate the effectiveness of Enhanced Recovery After Surgery (ERAS) protocols in patients undergoing elective hysterectomy. ERAS is an evidence-based perioperative approach designed to reduce surgical stress, accelerate recovery, and improve clinical outcomes. Participants will be randomized to receive either ERAS-based care or conventional perioperative management. The study will assess whether ERAS implementation reduces hospital stay and improves postoperative recovery without increasing complications.

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Key information

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

faculty of medicine-Cairo university

Cairo, Egypt

About this study

Enhanced Recovery After Surgery (ERAS) protocols are structured, multidisciplinary perioperative care pathways developed to optimize surgical outcomes by minimizing physiological stress and promoting early recovery. These protocols include preoperative counseling, shortened fasting with carbohydrate loading, opioid-sparing anesthesia, early feeding, and early mobilization.

Hysterectomy remains one of the most common gynecological procedures worldwide and is often associated with prolonged hospital stay and postoperative morbidity, particularly in resource-limited settings. While international evidence supports the benefits of ERAS in improving outcomes such as reduced length of hospital stay, improved pain control, and decreased complications, there is a need for locally generated data to validate its effectiveness in Egyptian tertiary healthcare settings.

This study will be conducted at Kasr Al-Ainy Hospital, Cairo University, and will include women undergoing elective hysterectomy for benign or early-stage malignant gynecological conditions. Participants will be randomly assigned to either the ERAS group or the conventional care group. Outcomes will be assessed during hospitalization and up to 30 days postoperatively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women aged 18-70 years.
  • Undergoing elective total hysterectomy for benign or early stage malignant gynacological conditions .
  • ASA ( American Society of Anesthesiologists ) physical status I-II.
  • Able to provide informed consent.

Exclusion criteria

  • Emergency hysterectomy
  • Advanced malignant requiring extensive debulking
  • Known bowel disease or previous bowel surgery ( crohn's disease , bowel obstruction )
  • Significant cognitive impairment or psychiatric illness
  • Inability to follow ERAS protocol (e.g., cognitive impairment)
  • Refusal to participate

Treatment and study plan

dextrose (5%)

Drug

IV dextrose infusion (5%) 500 ml once ,2-3 hours before anesthesia

ERAS protocols

Procedure

Reduced fasting Early oral feeding Early mobilization

Primary outcomes

  1. length of hospital stay (LOS)

    Time frame: From day of surgery up to 7 postoperative days

    Time from completion of surgery to hospital discharge readiness, measured in days.

Secondary outcomes

  1. postoperative pain score

    Time frame: At 12 and 24 hours postoperatively

    Postoperative pain intensity measured using the Visual Analog Scale (VAS), a 10-cm scale ranging from 0 (no pain) to 10 (worst imaginable pain).

  2. time to first bowel movement

    Time frame: Up to 5 postoperative days

    the interval (in hours) from completion of surgery to the first documented passage of stool."

Study contacts

Contact information is provided by the study sponsor or research team.

Ehab H Sorour, MD

CONTACT

[email protected]

+201112496821

Mohamed E El Mahy, MD

CONTACT

[email protected]

+201111831716

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effectiveness of Enhanced Recovery After Surgery (ERAS) Protocols in Hysterectomy Patients. A Prospective,Randomized Controlled Clinical Trial.

Acronym: ERAS

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
May 4, 2026
Registry last updated
May 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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