Enhanced Recovery After Intensive Care (ERIC)

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

The adherence [fulfilled yes/no] to this intra-hospital QI is daily assessed on a patient-level

Number of deaths from any cause within 6 months after enrolment including in-hospital mortality will be recorded (using hospital administrative records, electronic medical records, municipal personal records database and the 3- and 6-month follow-up with surrogates).

The patient-reported symptom burden on anxiety and depression will be assessed by the paper-based Patient-Health-Questionnaire PHQ-4 at month 3 and 6. Higher total scores indicate higher impairment.

Patient-reported symptom burden on post-traumatic stress will be assessed by the paper-based questionnaire Impact of Event Scale revised (IES-R) at month 6. Higher total scores indicate greater distress.

Cognitive functional outcome as assessed by the MiniCog test (2 tests: three-item recall task; clock-drawing task) at month 3 and 6. Higher scores indicate better cognitive functioning.

Cognitive functional outcome as assessed by the Animal Naming test at month 3 and 6. Higher scores indicate better cognitive functioning.

Patient's physical function, walking ability and risk of fall as assessed by the Timed Up & Go (TUG) test at month 3 and 6. Higher scores indicate a higher level of impairment.

Patient's muscle/ nerve function is assessed by the Hand grip strength (HGS) test (measured with a dynamometer, average strength [in kg] of three trials for the dominant hand) at months 3 and 6.

Patient's self-reported health-related quality of life as measured by the EuroQol - 5 Dimensions - 5 Level (EQ-5D-5L) Visual Analogue Scale (VAS) and the EQ-5D-5L descriptive system; the EQ-5D-5L VAS is a thermometer-like rating scale ranging from 0 (worst imaginable health state) to 100 (best imaginable health state).

Number of patients with organ dysfunction as assessed by general practitioner or study personnel/ investigator at month 3 and 6.

Self-perceived breathlessness as assessed by the Modified British Medical Research Council (mMRC) Dyspnea Scale at month 6. 5-point Likert scale [range 1 to 5] with a higher score indicating higher impairment.

Duration [in days] of mechanical ventilation after discharge from the ICU

Patient-reported General Disability Score as measured by the WHO Disability Assessment Schedule (WHODAS 2.0) for activity limitation and participation restriction, 12-item short version, self-administered questionnaire. The raw score is calculated by summing the values for each of the 12 questions. Higher scores indicate greater disability.

Patients will be followed for duration of stay. The total number of days spent in ICU will be assessed (inclusive of index ICU stay).

Patients will be followed for duration of hospital stay. The total number of days spent in a hospital will be assessed (inclusive of index ICU stay and index hospitalization).

Employment status at 3 months and 6 months after hospital discharge (including e.g. return to work, change in duties or change in effectiveness) at 3 and 6 months.

Health-related costs for standard care and supportive care will be estimated in Euros per patient per months. Data source will be GPs, hospital-electronic health records and health insurance data as well as publicly available data sources from the German reimbursement system.