Skip to main content
OpenTrials
Completed

NCT Number: NCT05403619

Enhanced FoCUS in Patients With Shortness of Breath

Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a focused cardiac Ultrasound with utilization of Doppler measurements.

The objectives were the therapeutic and diagnosis changes induced by eFoCUS. The primary endpoint was defined by the pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants associated with eFoCUS results.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Shortness of Breath Acute Respiratory Failure Cardiovascular Diseases Dyspnea Embolism Embolism and Thrombosis Infections Lung Diseases Pathological Conditions, Signs and Symptoms Pneumonia Pulmonary Embolism Respiration Disorders Respiratory Tract Diseases Respiratory Tract Infections Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Nantes University Hospital

Nantes, 44093, France

About this study

It was a retrospective observational study performed in a internal medicine ward of a French University Hospital. Patients were identified in the hospital database, pertinent features and eFoCUS findings were extracted and anonymized.

Inclusion criteria

  • Adult patients admitted to an internal medicine ward from the ED for acute shortness of breath.
  • Realization of an eFoCUS prescribed by the physician in charge of the patient

Exclusion criteria

  • Comprehensive echocardiography already performed Methods For each identified patient, pertinent data (demography, initial diagnosis and treatment (diuretics, antibiotics, anticoagulants)) and eFoCUS findings were extracted from the hospital files, anonymized and entered in a LibreOffice spreadsheet. Extracted diagnosis were gathered into the following categories: Community-acquired pneumonia (CAP), Acute cardiogenic pulmonary edema (ACPE), Pulmonary embolism (PE), Chronic Obstructive Pulmonary Disease (COPD) and other (OTHER).

Objectives and endpoints

  • The main objective was the therapeutic change induced by eFoCUS. The primary endpoint was defined by the pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants associated with eFoCUS results.
  • The secondary objectives were diagnosis modifications induced by eFoCUS. Data analysis
  • Numerical data were presented as mean ± SD or as median with interquartile range depending on the normality. The paired Student's t-test was used to compare normally distributed data. The chi-square test was used for the comparison of noncontinuous variables expressed as proportions. A p-value <0.05 was considered significant. All p-values were two-sided. Statistical analysis was realized with R (4.03.3) in the Rstudio® environment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients admitted to a internal medicine ward from the ED for acute shortness of breath.
  • Realization of an eFoCUS prescribed by the physician in charge of the patient

Exclusion criteria

  • Comprehensive echocardiography already performed

Treatment and study plan

Diagnostic Test

Diagnostic Test

Cardiac Ultrasound in order to explore the causes of shortness of breath

Other names: Focused cardiac Ultrasound

Primary outcomes

  1. Pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants

    Time frame: up to 24 hours after eFoCUS

    Number of patients for whom there was an introduction or discontinuation of diuretics, antibiotics or anticoagulants associated with Focused cardiac ultrasound

Secondary outcomes

  1. Changes of diagnostic categories associated with eFOCUS

    Time frame: up to 24 hours after eFoCUS

    Number of patients for whom the diagnostic category (pneumonia, acute cardiac failure, pulmonary embolism, COPD, other) was modified after Focused cardiac ultrasound

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Impact of an Enhanced Focused Cardiac Ultrasound on Treatment Modifications in a Population of Internal Medicine Patients: Retrospective Study

Acronym: eFOCUS

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Jun 3, 2022
Registry last updated
Jun 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.