Energy Homeostasis in Anorexia Nervosa

The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.

Completed

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Key information

Conditions

Anorexia Nervosa Feeding and Eating Disorders Mental Disorders

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

New York State Psychiatric Institute, Unit 98

New York, 10032, United States

About this study

Anorexia Nervosa (AN) is a psychiatric illness that is characterized by extreme weight loss and severe body image distortions. In this study, we are examining changes in body composition, metabolic rate, and reproductive function before and after treatment for AN. More specifically, we are testing the hypotheses that 1)Weight-restored patients with AN have elevated resting energy expenditure (REE) compared to controls, 2) Weight-restored patients with AN have a central disposition of body fat compared to controls, 3) Weight-restored patients with AN who gain the most fat centrally will have the least improvement on psychological measures, 4) Weight-restored patients with AN will have leptin levels out of proportion to body fat mass. It will also investigate the relationship between REE and leptin with respect to the return of menses.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Patients:

Inclusion criteria

DSM-IV diagnosis of Anorexia Nervosa
BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight)
Medically stable
Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2

Exclusion criteria

On medication*
Current substance abuse or dependence
History of suicide attempt or other self-injurious behavior within the previous 6 months
Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)

Controls:

Inclusion criteria

No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence)
No history of an eating disorder
BMI greater than 19kg/m2 and less than 21kg/m2
Weight stable (+/- 2kg) for the previous 6 months
No history of excessive or repeated dieting
No history of excessive exercise (defined as greater than 6 hours/week)
Regular menstrual cycles

Exclusion criteria

On medication*
Pregnant or lactating
Significant medical problem
Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)

At the time of testing, subjects will be free of fluoxetine for 6 weeks, and free of all other medications for a minimum of 2 weeks

Sponsors and collaborators

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Nih

Registry information

Important dates

Study start: 2000
Study completion: 2004
First posted: Aug 25, 2006
Registry last updated: Jan 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed