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Enrolling by Invitation

NCT Number: NCT03388476

Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension

Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for pulmonary hypertension as an easily measurable and cheap diagnostic tool in patients with suspicion of pulmonary hypertension.

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Key information

Conditions

Hypertension, Pulmonary Cardiovascular Diseases Chronic Thromboembolic Pulmonary Hypertension Familial Primary Pulmonary Hypertension Hypertension Hypertension;Pulmonary;Primary Lung Diseases Pulmonary Arterial Hypertension Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Clinic Giessen and Marburg

Giessen, Hesse, 35392, Germany

About this study

The disease pulmonary hypertension is due to a remodeling of the lung vessels which results in a change of the exhaled air. This change is measurable with a so called capnograph. The investigators want to measure the breath from patients with and without pulmonary hypertension to detect a cut-off value for the diagnosis pulmonary hypertension.

Patients which have the probably diagnosis pulmonary hypertension and are older than 18 years are investigated. This patients will get an right heart catheterization and a measurement from their exhaled air.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age > 18 years, suspicion of pulmonary hypertension, planned or accomplished right heart catheterization

Exclusion criteria

none

Treatment and study plan

Capnography

Diagnostic Test

Measuring of the exhaled air, especially endtidal co2, through capnography.

Primary outcomes

  1. Measurement PetCO2

    Time frame: At baseline

    Measurement PetCO2 by capnography at rest after or before a right heart catheterization, comparison of the parameter between patients with and without

Secondary outcomes

  1. Establishing a cut-off

    Time frame: At baseline

    Establishing a cut-off for the non-invasive diagnosing of pulmonary hypertension, which differs between patients with and without pulmonary hypertension and save patients without the disease before a dispensable invasive right heart catheterization

Sponsors and collaborators

Lead sponsor

University of Giessen

Other

Registry information

Official study title

Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension in Patients With Suspicion of Pulmonary Hypertension

Acronym: EARLIER

Important dates

Study start
2018
Primary completion
2030
Study completion
2035
First posted
Jan 3, 2018
Registry last updated
May 19, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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