Endothelial Glycocalyx Damage in Brain Death Organ Donors

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

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Key information

Conditions

Brain Damage Due to Hypoxia Behavior Brain Diseases Central Nervous System Diseases Hypoxia Hypoxia, Brain Nervous System Diseases Organ Donors Organ Transplant Failure or Rejection Pathological Conditions, Signs and Symptoms Rejection, Psychology Signs and Symptoms Signs and Symptoms, Respiratory Social Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Hradec Kralove

Hradec Králové, 50005, Czechia

Location status: Recruiting

Location contact

David Astapenko, MD, PhD

CONTACT

[email protected]

+420495833218

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients in critical condition declared as brain dead by clinical examination

Exclusion criteria

Treatment and study plan

Endothelial glycocalyx damage assessment

Diagnostic Test

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Primary outcomes

Markers of endothelial glycocalyx damage

Time frame: baseline at the time of inclusion

Levels of syndecan-1 in serum and urine

Study contacts

Contact information is provided by the study sponsor or research team.

David Astapenko, MD, PhD

CONTACT

[email protected]

+420495833218

Sponsors and collaborators

Lead sponsor

University Hospital Hradec Kralove

Other

Registry information

Official study title

Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors

Important dates

Study start: 2022
Primary completion: 2027
Study completion: 2027
First posted: Nov 8, 2022
Registry last updated: May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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