Endothelial Dysfunction as a Predictive Marker of Acute Graft-Versus-Host Disease in Adult Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Assess whether the CEC count in peripheral blood, analyzed at baseline T0, can predict the risk of acute GvHD onset.

Completed

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Key information

Conditions

GVHD

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, 27100, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged between 18 and 70 years old
First allogeneic hematopoietic stem cell (HSC) transplant for hematological disease
Use of HSCs from bone marrow, peripheral blood, or cord blood
Use of HLA-identical related donors, haploidentical related donors, HLA-identical registry donors, registry donors with mismatches at major HLA loci
Signing of informed consent

Exclusion criteria

Age < 18 years or >70 years
Patients receiving allogeneic HSC transplantation for non-hematologic disease
Second or subsequent allogeneic HSC transplantation

Treatment and study plan

Primary outcomes

Predict the risk of aGvHD onset.

Time frame: During the 18-month enrollment period, approximately 50 adult patients receiving HSCT are expected to be enrolled.

Assess whether the CEC count in peripheral blood, analyzed at baseline T0, can predict the risk of acute GvHD onset.

Sponsors and collaborators

Lead sponsor

Fondazione IRCCS Policlinico San Matteo di Pavia

Other

Registry information

Official study title

Endothelial Dysfunction as a Predictive Marker of Acute Graft-Versus-Host Disease in Adult Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (END-GAME)

Acronym: END-GAME

Important dates

Study start: 2021
Primary completion: 2022
Study completion: 2023
First posted: Apr 2, 2026
Registry last updated: Apr 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed