Endothelial Cell Loss After Phacoemulsification Intra and Supracapsular

Cataract is the clouding of the lens of the eye, which initially prevents clear vision and eventually progresses to blindness if left untreated. Cataract remains the leading cause of blindness and an important cause of visual impairment across the globe. Cataract surgery by ultrasonic phacoemulsification is the most common surgery practiced in France (600 000/year)

Two sub-categories of phacoemulsification coexist :

Endocapsulars techniques represented by Divide-and-Conquer and Phaco-Chop ; and Supracapsular techniques mainly represented by Subluxation (similar to Tilt-and-Tumble) The corneal endothelium plays an important role in maintaining the dehydrated state and the transparency of the cornea. Some degree of endothelial cell loss invariably occurs in all types of cataract surgery but the amount of endothelial cell loss may varies with the type of surgical technique The aim of the study is to evaluate the density of the central corneal endothelial cells before and after cataract surgery comparing two phacoemulsification techniques (Divide-and-Conquer vs Subluxation)

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Key information

Conditions

Cataracts Cataract Eye Diseases Lens Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chr Metz Thionville

Metz, 57085, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female aged ≥ 18 years
Patients undergoing cataract surgery
Visual acuity Monoyer scale <6/10e (< +0.2 logMar)
Nuclear, cortical and posterior subcapsular cataract with normal density to severe in the LOCSIII classification

Exclusion criteria

insulin-dependent diabetes and /or diabetic retinopathy
corneal disease: keratitis, dystrophy, corneal degeneration
Any disease of intraocular pressure
Any disease of the anterior segment
Low preoperative endothelial cell density < 1500 c/mm²
Combined surgery (cataract + corneal transplant, cataract + glaucoma surgery, cataract +vitrectomy ...)
Risk factors for surgical per-operative complication
Pregnancy, lactation
Ward of court
Patient not covered by the Social Security scheme

Treatment and study plan

Subluxation

Procedure

One pole of The nucleus is hydrodissected until it lilts above the capsular bag. The tilted nucleus is rotated to face the incision and remaining half nucleus is then tumbled and emulsification continues from the opposite equator outside in until complete

Divide and conquer

Procedure

Cataract nucleus is fragmented into 4 pieces then aspirated by ultrasonic vibration

Primary outcomes

Main Outcome Measures: postoperative Endothelial cell loss of the central corneal

Time frame: 12 month

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Metz-Thionville

Other

Registry information

Acronym: PERCEPOLIS

Important dates

Study start: 2015
Primary completion: 2017
Study completion: 2018
First posted: Aug 31, 2015
Registry last updated: Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed