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Active, Not Recruiting

NCT Number: NCT07600112

Endoscopic Versus Conventional Parotidectomy for Benign Parotid Tumors

To compare endoscopic and conventional parotidectomy in the management of benign parotid tumors regarding surgical outcomes, facial nerve preservation, operative time, postoperative complications, and cosmetic results, in order to evaluate the safety, feasibility, and potential advantages of the endoscopic minimally invasive technique.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of General Surgery, Maxillofacial and Head and Neck Unit

Asyut, 2063045, Egypt

About this study

Parotid gland tumors account for approximately 3-6% of all head and neck tumors, and nearly 70-80% arise from the superficial lobe of the gland, with the majority being benign lesions such as pleomorphic adenoma and Warthin tumor . A considerable proportion of these tumors occur in the inferior pole of the parotid gland, where surgical management aims to achieve complete tumor excision while preserving facial nerve function and maintaining satisfactory cosmetic outcomes .

Conventional parotidectomy performed through a modified Blair incision remains the standard surgical approach for benign parotid tumors . This technique offers adequate surgical exposure and good tumor control; however, it is associated with several limitations including visible facial scarring, potential facial nerve injury, Frey's syndrome, and postoperative sensory disturbances .

In recent years, minimally invasive surgical approaches have been introduced to overcome these limitations. Endoscopic parotidectomy has emerged as a promising technique for selected benign parotid tumors. The magnified endoscopic view may facilitate more precise dissection and improved identification of facial nerve branches while allowing smaller incisions and potentially better cosmetic outcomes .

Despite encouraging results reported in several studies, the available evidence comparing endoscopic parotidectomy with the conventional approach remains limited. Therefore, further prospective comparative studies are required to evaluate the safety, efficacy, and cosmetic advantages of this minimally invasive technique.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Patients with benign parotid tumors involving the superficial lobe of the parotid gland
  • Tumors located in the inferior pole with or without limited deep lobe extension
  • Tumor size suitable for minimally invasive approach ≤4 cm
  • Patients fit for surgery under general anesthesia
  • Patients willing to provide informed consent and comply with follow-up

Exclusion criteria

  • Recurrent parotid tumors
  • Previous parotid surgery on the affected side
  • Pre-existing facial nerve dysfunction
  • Previous neck surgery or extensive cervical/anterior chest wall scarring
  • Significant comorbidities contraindicating surgery or general anesthesia
  • Suspected or confirmed malignant parotid tumors

Treatment and study plan

Endoscopic Parotidectomy Group

Procedure

Minimally invasive endoscopic-assisted parotidectomy performed through anterior chest wall approach for benign parotid tumors.

Active Comparator Intervention Conventional Parotidectomy

Procedure

Conventional open parotidectomy performed through modified Blair incision for management of benign parotid tumors.

Primary outcomes

  1. Surgical safety and feasibility

    Time frame: During surgery and up to 3 months postoperatively.

    Assessment of intraoperative and postoperative complications and conversion rate to open surgery.

  2. Facial nerve function

    Time frame: 24 hours, 1 week, 1 month, and 3 months postoperatively.

    Assessment using House-Brackmann grading system.

Secondary outcomes

  1. Intraoperative blood loss

    Time frame: Intraoperative

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Endoscopic Versus Conventional Parotidectomy in the Management of Benign Parotid Tumors : A Prospective Comparative Study

Acronym: miniparo

Important dates

Study start
2026
Primary completion
2026
Study completion
2028
First posted
May 20, 2026
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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