Endoscopic Therapy for Laterally Spreading Tumors (LSTs)

This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of Medicine; First Affiliated Hospital of Huzhou University; The Second Hospital of Jiaxing; Jinhua People's Hospital; Lanxi People's Hospital) from 2020.05.01 to 2023.04.30 with the purpose of comparing the efficacy and safety of hybrid ESD and ESD in the treatment of colorectal LST. The complete resection rate, operation time, operation cost, intraoperative and postoperative complications of hybrid ESD and ESD LST will be compared. To provide strong evidence for the selection of endoscopic treatment strategies for LST.

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Key information

Conditions

To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, 310009, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years old;
LST lesion diameter >1cm;
Medical record data integrity

Exclusion criteria

Pedicle lesions;
Resection of residual lesions after endoscopic treatment;
Advanced endoscopic imaging showed submucosal infiltrating lesions.
The lesions are in patients with inflammatory bowel disease;
Familial polyposis;
Electrolyte abnormalities;
Coagulation dysfunction;
Pregnant or lactating patients;
Taking nonsteroidal anti-inflammatory drugs or anticoagulants;
A history of alcoholism;
Severe organ failure;
Medical records are incomplete

Treatment and study plan

Conventional ESD

Procedure

Conventional ESD is the most suitable method for total resection, especially for large lesions. This method can complete the resection of early gastrointestinal cancer and precancerous lesions, while maintaining the integrity of digestive tract anatomy and physiological function.The operation difficulty of this technique is high, the equipment requirements are high, the operation time is long, and the complication rate is closely related to the technical level of the operator.

Hybrid ESD

Procedure

Hybrid ESD is a better choice, but only can remove the lesion in one piece, but also has a lower technical difficulty than conventional ESD

Primary outcomes

complete resection rate

Time frame: 2 weeks

One-time complete excision

Sponsors and collaborators

Lead sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other

Registry information

Official study title

Hybrid Versus Conventional Endoscopic Submucosal Dissection for Laterally Spreading Tumors (LSTs): A Retrospective Multicenter Study

Acronym: LST

Important dates

Study start: 2020
Primary completion: 2023
Study completion: 2023
First posted: Jun 18, 2024
Registry last updated: Jun 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.