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Completed

NCT Number: NCT02193646

Endoscopic Size Assessment of Advanced Adenomatous Polyps

The investigators are retrospectively comparing detection rates of adenomatous polyps, advanced adenomas, and size assessment of the polyps among Rush University Medical Center endoscopists. The investigators plan to review whether the size assessment of adenomatous polyps affected the surveillance protocols and if the location of polyps detected affected the detection rates.

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Key information

Conditions

Adenoma Detection Rate Improvement in Screening Colonoscopy Adenoma Neoplasms Neoplasms by Histologic Type Neoplasms, Glandular and Epithelial

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Amanda Lin

Chicago, Illinois, 60612, United States

About this study

The study plans to compare detection rates of adenomatous as well as the sessile serrated polyps, advanced adenomas and size assessment of the polyps among the endoscopists at the study site. In addition, the study team aims to evaluate rates of advanced neoplasia on surveillance colonoscopy based on certain features on initial colonoscopy and patient characteristics, including specific high-risk histologic features and concurrent medication usage such as aspirin. In addition, patients with at least one adenoma on surveillance colonoscopy will be identified and regarded as cases. Cases will be compared against normal surveillance colonoscopy. The Controls will be selected on a 1:1 ratio. Aspirin use will be compared between groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of adenomatous polyps detected at endoscopy and diagnosed pathologically by tissue biopsy
  • Have a colonoscopy at RUMC for screening purposes

Exclusion criteria

  • Failure to meet inclusion criteria
  • Previous diagnosis of IBD or colorectal cancer

Treatment and study plan

Primary outcomes

  1. Adenomatous Polyp Detection Rate

    Time frame: one year

    Assessing for advanced adenomas (including location).

  2. Endoscopic Size Assessment Versus Pathological Size Assessment

    Time frame: one year

    Size of polyps at time of endoscopic procedure will be compared to the size of the same polyp by pathological assessment.

Secondary outcomes

  1. Retroflexion as an indication of adenoma detection rate in colorectal cancer screening

    Time frame: one year

    Retroflexion is a common but not mandatory practice in colonoscopy which as not been systematically studied in terms of polyp detection. Charts will be reviewed to determine whether retroflexion was performed.

Sponsors and collaborators

Lead sponsor

Rush University Medical Center

Other

Registry information

Official study title

Endoscopic Size Assessment of Advanced Adenomatous Polyps; Inter Observer Variations

Important dates

Study start
2010
Primary completion
2025
Study completion
2025
First posted
Jul 17, 2014
Registry last updated
Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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