Endoprosthetic Replacement for Pathological Fractures of the Hip: A 35-year Update

This study will be based on a retrospective review of patients who received endoprosthetic reconstruction for pathologic fracture of the proximal femur. The objectives would be two-fold: (1) to compare rates ofambulation, pain, and survival to the historic cohort and (2) to identify predictors of ambulation in the current population.

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Key information

Conditions

Hip Fractures Femoral Fractures Fractures, Bone Fractures, Spontaneous Hip Fracture Pathologic Hip Injuries Leg Injuries Pathological Fracture Pathological Fracture of Hip Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants have received endoprosthetic reconstruction for pathologic fracture of the proximal femur

Exclusion criteria

Participants with fractures greater than 3mm from the lesser trochanter
Participants without histopathologic confirmation of tumor

Treatment and study plan

Data collection and analysis

Other

Patient data will be analyzed to ensure that all data fields are available and that suitable sample size is available to answer the research objectives. The rate of ambulation at discharge, ambulation at 3 month follow up (if available), time to death, and pain score between the historic cohort with a current cohort of patients will be compared.

Primary outcomes

Comparison of rates of ambulation, pain, and survival to the historic cohort

Time frame: up to 10 years

This study will be based on a retrospective review of patients who received endoprosthetic reconstruction for pathologic fracture of the proximal femur.

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2026
Study completion: 2026
First posted: Apr 18, 2025
Registry last updated: Apr 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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