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NCT Number: NCT05779462

ENDOMETRIOSIS - MRI

Endometriosis is a frequent pathology with an estimated prevalence of 10% of women of childbearing age. There is no exact correspondence between the symptoms described by the patients and the severity of the lesions, which makes clinical diagnosis difficult. It therefore seems important to improve the complementary examinations available to make the diagnosis more precise and to better study the effectiveness of the treatments implemented. The clinical examination and per-surgical findings of patients with deep pelvic endometriosis show a clear decrease in the mobility of the pelvic organs in relation to each other, but few studies have looked at this mobility, which could however have an implication in explaining the pathophysiology of the disease and the symptomatology of the patients, as well as in the detection of lesions preoperatively. The persistence of hypo-mobility could also help to understand treatment failures.

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Key information

Conditions

Endometriosis Comparative Study Diagnosis Disease Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Magnetic Resonance Imaging Mobility Limitation Pathologic Processes Pathological Conditions, Signs and Symptoms Pelvis Signs and Symptoms Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Service de chirurgie gynécologique Hôpital Jeanne de Flandre - CHU de LILLE

Lille, France

Location status: Recruiting

Location contact

CHRYSTELE RUBOD DIT GUILLET,

CONTACT

[email protected]

0320446757

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient referred for suspected pelvic endometriosis requiring pelvic MRI
  • Female, nulliparous,
  • patient with signed written consent, patient with health insurance,
  • patient willing to comply with all study procedures and duration

Exclusion criteria

  • BMI > 35,
  • history of hereditary collagen and elastic tissue disease,
  • history of pelviperitonitis,
  • history of major pelvic surgery,
  • inability to receive informed information,
  • inability to participate in the entire study,
  • lack of social security coverage,
  • refusal to sign consent

Treatment and study plan

Dynamic MRI Sequence

Other

Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care

Primary outcomes

  1. the mean vertical displacement (in millimeters) measured on the anterior wall of the vagina between rest and maximum pushing force during dynamic MRI

    Time frame: Baseline

Secondary outcomes

  1. the mean vertical displacement (in millimetres) measured on the cervix between rest and maximum thrust effort during dynamic MRI.

    Time frame: Baseline

  2. the mean vertical displacement (in millimetres) measured on the posterior wall of the vagina between rest and maximum pushing force during dynamic MRI.

    Time frame: Baseline

  3. the measurement of variation in mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort between the initial dynamic MRI of patients with

    Time frame: Baseline

  4. the statistical association between the symptoms of patients with endometriosis and the mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort during dynamic MRI.

    Time frame: Baseline

    Initial symptoms are associated with initial dynamic MRI data and post therapeutic symptoms are associated with post-therapeutic dynamic MRI data.

    The symptoms of interest are dysmenorrhea, non-cyclic pelvic pain, dysuria, dychesia, transit disorders (diarrhea/constipation), and dyspareunia.

Study contacts

Contact information is provided by the study sponsor or research team.

Chrystele RUBOD, MD,PhD

CONTACT

[email protected]

0320445962

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

Study of Pelvic Organ Mobility by Dynamic MRI in Pelvic Endometriosis

Acronym: ENDO-MRI

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Mar 22, 2023
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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