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OpenTrials
Completed

NCT Number: NCT01245309

Endometrial Scratching Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization With Previous IVF Failure

Scratching the linning of the womb before IVF cycle could increase the chances of having a baby after an IVF cycle.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

Up to 40 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

Mansoura University

Al Mansurah, 53111, Egypt

About this study

All women with history of RIF (as defined by ESHRE) and who wish to undertake another assisted conception treatment cycle are invited to participate in the trial. Women will be randomised to two arms; one undergoing endometrial sampling and control. Women in the experimental arm will be subjected to endometrial scrapping with Pipelle biopsy catheter two times; on days 21 and 26 of the cycle prior to the IVF index cycle and after initiation of the GnRHa in the long agonist protocol. Women in the control group will undergo a placebo procedure using the uterine sound on the same days of the cycle like women in the intervention group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

WOMEN WITH PREVIOUS IVF FAILURE UNDERGOING IVF TREATMENT

-

Exclusion criteria

  • WOMEN>40 YEARS OLD WOMEN UNDERGOING THEIR FIRST IVF TREATMENT CYCLE

Treatment and study plan

Scratching

Procedure

endometrial scratching before COH in IVF

A PLACEBO PROCEDURE

Procedure

A PLACEBO PROCEDURE

Primary outcomes

  1. live birth rate per woman

    Time frame: 9 months

Secondary outcomes

  1. ongoing pregnancy rate

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Endometrial Injury Prior to Controlled Ovarian Stimulation (COH) in Women Undergoing In-vitro Fertilization in Women With Previous IVF Failure.

Acronym: ESICOHF

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Nov 22, 2010
Registry last updated
Jan 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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