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Completed

NCT Number: NCT00837733

Endometrial Local Injury and Implantation Failure

The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

15 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Research and Clinical Center for Infertility

Yazd, Yazd Province, 8916877391, Iran

About this study

In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group.

The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred

Exclusion criteria

  • age over than 40 years old
  • poor responders to ovarian stimulation

Treatment and study plan

endometrial biopsy

Procedure

Endometrial biopsy was done at luteal phase on the day 21-26 of spontaneous menstrual cycles, when GnRH agonist uses begun. Endometrial samples were taken by a biopsy catheter

Other names: biopsy catheter (Pipelle de Cornier, Prodimed, France

Primary outcomes

  1. Implantation Rate,Chemical pregnancy rate, Clinical pregnancy rate

    Time frame: One year

Sponsors and collaborators

Lead sponsor

Yazd Research & Clinical Center for Infertility

Other

Collaborators

  • Yazd Medical University

Registry information

Official study title

Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Feb 5, 2009
Registry last updated
Feb 5, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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