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Completed

NCT Number: NCT03886883

Endogenous Modulation of Pain and Stretch Tolerance

This study investigates the role of two endogenous inhibitory mechanisms; exercise-induced hypoalgesia (EIH) and a conditioning painful stimulus (CPM) on passive joint range of motion, passive resistive torque and pain sensitivity. The study is a randomized, repeated-measures cross-over study.

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Key information

Conditions

Pain Threshold

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University College of Northern Denmark

Aalborg, 9220, Denmark

About this study

The increase in range of motion following stretching is related to changes in the tolerance to stretch. The mechanistic relationships behind these changes in subject sensation are however unknown but could be related to endogenous modulation of pain.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Eligibility for participation included the absence of any pain or other conditions that might affect the somatosensory system.

Exclusion criteria

  • Substance abuse, History of neurological or mental disabilities, Lack of ability to comply with instructions, Delayed onset of muscle soreness.

Treatment and study plan

Exercise induced hypoalgesia (EIH)

Other

An EIH response was induced by a 3-minute isometric contraction of the hand flexor muscles at 25% of maximal voluntary contraction (MVC).

Static stretch (SS)

Other

Two bouts of 30 seconds of static stretching (SS) of the knee flexors.

Rest

Other

The participants rested in a seated position for 10 minutes

Conditioned pain modulation (CPM)

Other

A CPM response was induced by way of the cold pressor test.

Primary outcomes

  1. Knee extension range of motion

    Time frame: Passive knee extension range of motion was measured as a baseline just prior to the induction of exercise-induced hypoalgesia (EIH), Static stretch (SS), Rest and a conditioning painful stimulus (CPM)

    Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

  2. Knee extension range of motion

    Time frame: Passive knee extension range of motion was measured 30 seconds after the induction of EIH, SS, Rest and CPM

    Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

  3. Knee extension range of motion

    Time frame: Passive knee extension range of motion was measured 10 minutes after the induction of EIH, SS, Rest and CPM

    Passively induced knee extension range of motion was measured using the Biodex system 4 pro isokinetic dynamometer

Secondary outcomes

  1. Passive resistive torque

    Time frame: Passive resistive torque was measured as a baseline just prior to the induction of EIH, SS, Rest and CPM

    Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.

  2. Passive resistive torque

    Time frame: Passive resistive torque was measured 30 seconds after the induction of EIH, SS, Rest and CPM

    Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.

  3. Passive resistive torque

    Time frame: Passive resistive torque was measured 10 minutes after the induction of EIH, SS, Rest and CPM

    Passive resistive torque during the passive knee extension motion was measured using the Biodex system 4 pro isokinetic dynamometer.

  4. Pressure pain thresholds

    Time frame: Pressure pain thresholds were measured as a baseline just prior to the induction of EIH, SS, Rest and CPM

    Pressure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.

  5. Pressure pain thresholds

    Time frame: Pressure pain thresholds were measured 30 seconds after the induction of EIH, SS, Rest and CPM

    Pressure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.

  6. Pressure pain thresholds

    Time frame: Pressure pain thresholds were measured 10 minutes after the induction of EIH, SS, Rest and CPM

    PRessure pain thresholds was measures using a handheld pressure algometer (Somedic AB, Hörby, Sweden.

Sponsors and collaborators

Lead sponsor

University College of Northern Denmark

Other

Registry information

Official study title

Endogenous Modulation of Pain - the Tolerance to Stretch

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Mar 22, 2019
Registry last updated
Mar 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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