Endogenous Lithium Clearance in Acute Kidney Injury

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness.

Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Kidney Injury Due to Sepsis Lithium Clearance Proximal Tubule Function

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital of North Norway

Tromsø, Troms, 9038, Norway

About this study

Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ICU patients diagnosed with AKI, without AKI and healthy controls

Exclusion criteria

Treatment and study plan

Lithium clearance

Diagnostic Test

Blood and urine samples

Primary outcomes

Renal lithium clearance

Time frame: 2 days

Clearance of lithium from the body

Sponsors and collaborators

Lead sponsor

University Hospital of North Norway

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2025
Study completion: 2025
First posted: Aug 8, 2023
Registry last updated: Jun 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed