ENDOCUR - Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight Adults

Chronic diseases such as diabetes, cardiovascular diseases and cancer are a major burden on the Scottish population. Obesity and inflammation have strong links to these diseases. One of the mechanisms explaining the relationship between low-grade inflammation and excess weight is "endotoxaemia". We wish to study this phenomenon, when small components coming from our gut bacteria can pass into the bloodstream, raising the body's defences. Diet can modulate endotoxaemia. In this study, we propose to use curcumin, in a capsule form, to modulate endotoxaemia. Curcumin comes from turmeric, which is widely used as a spice. In this study, we want to test the effect of consuming curcumin extract to the composition of the gut microbiota, post-meal endotoxaemia, and inflammatory markers in blood.

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Key information

Conditions

Overweight Bacteremia Body Weight Endotoxemia Infections Inflammation Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Signs and Symptoms Systemic Inflammatory Response Syndrome Toxemia

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI > 25 kg/m2.

Exclusion criteria

having chronic inflammatory or autoimmune disease, gastrointestinal complaints or known biliary obstruction (past and present)
use of anti-inflammatory drugs 2 weeks before the start of the study
use of antibiotics during the 12 weeks preceding the trial
pregnancy
lactation

Treatment and study plan

BCM-95

Dietary Supplement

Consuming 1 capsule of BCM-95 per day.

Other names: Bio-Curcumin

Placebo

Dietary Supplement

Consuming 1 placebo capsule per day

Primary outcomes

Level of endotoxin in plasma.

Time frame: 21 days

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight Adults

Acronym: ENDOCUR

Important dates

Study start: 2015
Primary completion: 2018
Study completion: 2018
First posted: Nov 6, 2017
Registry last updated: Apr 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed