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OpenTrials
Completed

NCT Number: NCT01823367

Encourage Healthy Families

This study is a randomized intervention that will test two different approaches reflecting diverse levels of both intensity and cost, to achieving risk reduction of T2D. This will help address a critical question in the translation of primary prevention research into the public health: how much intensity (and thus cost) is required to achieve an effective outcome? In addition, the proposed study will address a critical need in diabetes prevention that has not received sufficient scholarly attention: the prevention of T2D in children. No studies of diabetes prevention similar in scope to the DPP have been performed in school-aged children; however, reducing childhood obesity is widely accepted as the primary pathway to decreasing the growing prevalence of T2D in the pediatric population.

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Key information

Age range

8 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States

About this study

The proposed interventions will target mothers with a history of Gestational Diabetes (GDM), who gave birth to babies 9 pounds or greater, or who have prediabetes who are thus at very high risk for developing diabetes, and by virtue of their GDM/prediabetes, their children are also at high risk. Because of the genetic components involved, all children born by a woman afflicted with gestational diabetes mellitus or prediabetes have elevated risk of developing Type 2 Diabetes. This first intervention builds upon the evidence-based curriculum used in the DPP and incorporates into the curriculum detailed education regarding ways to help their children adopt healthier lifestyle behaviors. It will be delivered in groups of mothers only at community sites using trained laypeople. The second intervention will use the same parent curriculum, but adds a group program for children that teach them (directly) strategies for eating better and increasing physical activity. This program will be delivered to both mothers and children in separate groups. The group sessions will take place at the same time and in the same location by a trained facilitator.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult females, age 18 or greater
  • Body-mass index of ≥ 25 kg/m2
  • Is a biological mother to a child between 8 and 15 years of age (child must live with biological mom)
  • Is a biological mother with past diagnosis or history of gestational diabetes, prediabetes or gave birth to a child who weighed 9 pounds or greater at delivery
  • Child, ages 8 to 15 years, to biological mother meeting inclusion criteria for Adult Females

Exclusion criteria

  • Biological mother or biological child with diagnosis of Type 1 or 2 Diabetes Mellitus
  • Biological mother or biological child with current A1c > 6.5%
  • Biological mother or biological child current casual capillary blood glucose > 220mg/dl
  • Biological mother or biological child with uncontrolled hypertension (Systolic Blood Pressure (SBP) >180 mmHg or Diastolic Blood Pressure (DBP) >105 mmHg)
  • Biological mother or biological child with heart attack, stroke, or transient ischemic attack in the past 6 months
  • Biological mother or biological child with chest pain, dizziness, or fainting with physical exertion
  • Biological mother or biological child with Chronic Obstructive Pulmonary Disease (COPD) or asthma requiring home oxygen
  • Biological mother or biological child with cancer treatment in the last 5 years
  • Biological mother or biological child with any other known condition that could limit ability to become physically active or limit life span to <5 years
  • Biological mother or biological child with history of anti-diabetic medication use (oral agents or insulin) except during past gestational diabetes
  • Biological mother or biological child with self-report of any other condition associated with disordered glucose metabolism (including but not limited to):pregnancy; Cushing's syndrome; acromegaly; pheochromocytoma; chronic pancreatitis
  • Biological mother or biological child with conditions or behaviors likely to affect the conduct of the study (including but not limited to): any reported developmental problems, unable or unwilling to provide informed consent/assent, unable or unwilling to communicate with study staff or engage in learning activities

Treatment and study plan

Diabetes Prevention Program (DPP)

Behavioral

Diabetes Prevention Program (DPP): This is an evidence-based curriculum that has shown that it is possible to prevent or delay Type 2 Diabetes (T2D) in individuals if they keep a healthy weight, eat a nutritious diet, and stay physically active.

Primary outcomes

  1. Changes in weight

    Time frame: 3, 6, and 12 months after the beginning of the assigned intervention program

    Weight taken during data collection visits

Secondary outcomes

  1. Changes in diet

    Time frame: 3, 6, and 12 months after the beginning of the assigned intervention program

    Assessed by the Food Frequency Questionnaire (FFQ)

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

  • Indiana Clinical and Translational Sciences Institute
  • Regenstrief Institute, Inc.
  • The JPB Foundation
  • The YMCA of Greater Indianapolis

Registry information

Official study title

Primary Prevention of Diabetes in Children and Mothers at Increased Risk: Encourage Healthy Families.

Acronym: Encourage

Important dates

Study start
2012
Primary completion
2016
Study completion
2016
First posted
Apr 4, 2013
Registry last updated
Aug 25, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.