EMR Versus CSP in the Treatment of Sessile Serrated Lesions Less Than 10mm in Size

• Patients are undergone screening, surveillance, or therapeutic colonoscopy at the Endoscopy department of Gastrointestinal endoscopy center of Huadong hospital affiliated to Fudan University.
• Randomize patients with suspicious sessile serrated lesions (SSLs) less than 10mm in size into 2 interventional groups based on Random function of Statistical Package for the Social Sciences (SPSS) 20.0, including (1) Group 1: Endoscopic mucosal resection (EMR) and (2) Group 2: Cold snare polypectomy (CSP).
• Collecting variables which consist of primary and secodary outcomes.

Inclusion criteria

• Aged between 35 and 75 years
• Suspected sessile serrated lesions less than 10mm in size in screening, surveillance or therapeutic colonoscopy
• 0-Is or 0-IIa according to Paris classification
• Type 1 according to NICE and JNET classification
• Type II according to pit pattern
• Patients must sign an informed consent form prior to registration in study

Exclusion criteria

• Unsuitable for removal by EMR or CSP
• Suspected dysplasia or malignancy
• Recurrent sessile serrated lesions after endoscopic resection
• Familial adenomatous polyposis, Lynch syndrome or serrated polyposis syndrome
• History of inflammatory bowel disease
• Patients taking anticoagulant and antiplatelet agents before the examination
• Severe illness or other high-risk conditions that prevent the patient from cooperating with or tolerating endoscopic therapy
• Refusal to sign the informed consent form or any other factors that are not suitable for enrollment or affect the ability to participate in the study