Empagliflozin's Microcirculatory Effects in Cardiogenic Shock: an Ancillary Pilot Study of the EMPASHOCK Trial

This ancillary pilot study, conducted in an ICU, investigates the real-time microcirculatory effects of empagliflozin in patients with cardiogenic shock (CS). The study aims to determine if the drug improves microcirculation, which is a known predictor of patient outcomes in CS.

Upon a patient's inclusion in the main EMPASHOCK trial, consent for this ancillary study is obtained from the patient's family, with direct patient consent sought later if their condition improves.

The study involves two data collection points:

Baseline (H0): Before empagliflozin administration, a videomicroscope is used to capture sublingual microcirculation images. These images are analyzed using MicroTools software to measure key microcirculatory parameters. Standard macrocirculatory parameters (blood pressure, cardiac output) are also recorded.

48 Hours (H48): The same microcirculatory and macrocirculatory data are collected again to assess changes following treatment.

For patients in the non-empagliflozin group, assessment will be perform at inclusion (H0) and at H48.

The study's primary outcomes are the changes in these parameters over 48 hours, along with the patient's survival status at day 28.

Inclusion criteria

• Patient included in the main EMPASHOCK study
• Patient has signed a consent form for the ancillary study
• Patient is over 18 years old
• Hospitalized in the Intensive Care Unit for cardiogenic shock*
• Has been or is on catecholamines for at least 12 hours for the treatment of cardiogenic shock**
• Patient has the ability to take tablets orally
• Person is affiliated with or a beneficiary of a social security system

Exclusion criteria

• • GFR < 20 ml/min/1.73m²

• Chronic dialysis
• Patient on SGLT2 inhibitors prior to ICU admission
• Known allergy to SGLT2 inhibitors or any of their excipients (in particular, patients with hereditary galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption syndrome).
• Patient on lithium
• Patient with type 1 diabetes
• Patient in shock due to another cause or moribund patient (IGS 2 > 90)
• Cardiogenic shock cases excluded in the EMPASHOCK study: a. Heart transplant recipient or on a transplant list. b. Peripartum, adrenergic, valvular, restrictive, or post-embolic cardiomyopathy. c. Related to cardiotropic drug intoxication. d. Secondary to cardiac arrest where the patient remains comatose before inclusion.
• Woman of childbearing age without effective contraception
• Person referred to in Articles 10, 31, 32, 33, and 34 of EU Regulation 536/2014, specifically:
• Pregnant woman, woman in labor, or breastfeeding mother
• Minor person (not emancipated)
• Adult person subject to a legal protection measure (guardianship, curatorship, legal safeguard)