Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide

Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability.

This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls.

The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.

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Key information

Conditions

Suicide Behavior Behavioral Symptoms Self-Injurious Behavior

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rennes university hospital

Rennes, 35000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Right-handed,
Depressed suicide attempters for the first group,
Depressed patients with past history of suicidal acts for the second group,
Depressed patients with no history of suicidal acts for the third group,
Healthy controls for the fourth group.

Exclusion criteria

Another psychiatric trouble than depression,
Another psychotrope treatment than SSRI/SNRI and/or benzodiazepine at inclusion and/or one month before,
For the first and secand groups : more than fous suicidals acts within the past 3 years,
Deficits that do not allow test realisation (visual audition troubles, cognitif deficits,
Prosopagnosia,
Pregnancy,
Severe central nervous system disease or somatic disease,
MRI contra-indication,
Major benefiting from a legal protective measure,
No coverage care.

Treatment and study plan

fMRI

Other

two fMRI paradigms, emotional prosody recognition and decision making

Primary outcomes

fMRI activation area

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Acronym: EMODES

Important dates

Study start: 2013
Primary completion: 2018
Study completion: 2019
First posted: Sep 15, 2016
Registry last updated: Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed