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OpenTrials
Completed

NCT Number: NCT04069676

Emotional Proactive Brain Study in Adults With Autism Spectrum Condition

This project aims:

* to study behavioral and cerebral activity specificity (latency and amplitude of evoked potentials, time frequency maps and cerebral connectivity) in predictive process (top-down regulation) during visual recognition of static and dynamic stimuli in adults participants with autism spectrum conditions compared to typically developed participants. * to study the relation between predictive process and autonomous response (heart activity and electrodermal activity) * to explore potential sex differences between autistic males and females

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Key information

Conditions

Autism Spectrum Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Grenoble Alpes

Grenoble, 38043, France

About this study

Once eligibility criteria would have been verified, information on the study will be given and non opposition of the participant will be collected.Then, the participant will be comfortably installed in order to pass the Landolt C task (visual acuity task) on a computer. If his vision is normal, electroencephalogram (EEG), electrocardiogram (ECG) and electrodermal activity (EDA) of participants, will be recorded during visual processing and recognition tasks. Stimuli will include emotional and non emotional pictures and films, filtered in coarse-to-fine versus fine-to-coarse sequences in order to stimulate or not predictive process described by Bar (2007).

The participant will also have to complete an abbreviated version of the Wechsler Adult Intelligence Scale, IVth edition (Wechsler, 2003), and the Autism Spectrum Quotient (Baron-Cohen et al., 2001) if he never did it before. The aim is to pair as much as possible group by IQ and to verify that control participants don't present autistic traits above the Autism Spectrum Quotient cutoff. Groups will also be paired by age and education level.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • affiliation to the french social protection care
  • information and non opposition of the participant
  • information and non opposition of tutor/curator if the case presented
  • normal or corrected to normal vision
  • capacity to understand and apply instruction required by the task
  • no participation in another research
  • for autistic person: formal diagnosis of autism spectrum condition (autism/asperger/PDD-NS) according to CIM-10/DSM-IV/DSM-5 criteria

Exclusion criteria

  • adults with no ability to express their consent
  • adults on judiciary protection
  • perceptive/motor/neurological/psychiatric issue
  • major health issue (cardiac, metabolic ...)
  • alcohol or drug consumption

Treatment and study plan

EEG

Other

EEG, ECG and EDR record during a behavioral task

Other names: ECG, EDR

Primary outcomes

  1. Differences between autistic and typically developed participants in evoked potentials related to prediction mechanisms during visual processing

    Time frame: 55 minutes recording

    • differences in evoked potentials (latency and amplitude) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity.

  2. Differences between autistic and typically developed participants in behavioral responses related to prediction mechanisms during visual processing

    Time frame: 55 minutes (same recording as before)

    • differences in behavioral responses (reaction time and correct response rate) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding behavioral response.

Secondary outcomes

  1. Differences between groups in oscillatory activity

    Time frame: 55 minutes (same record as before)

    -differences in time-frequency maps. Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity.

  2. Difference between groups in cerebral connectivity

    Time frame: 55 minutes (same record as before)

    • differences in Dynamic Causal Modeling Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding cerebral activity.

  3. Differences between groups in autonomous activity

    Time frame: 55 minutes (same record as before)

    • ECG activity (HRV analysis)
    • electrodermal activity (EDA) Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated how predictive mechanism during visual perception are affected in autism regarding autonomous activity.

  4. Sex differences

    Time frame: 55 minutes (same record as before)

    • sex differences analysis Changes will be assessed between coarse-to-fine and fine-to-coarse sequencies. It will be used to investigated the existence of sex differences in autism regarding predictive process during visual perception.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

  • Laboratoire de Psychologie et NeuroCognition

Registry information

Acronym: PREDEMAUT

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Aug 28, 2019
Registry last updated
May 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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