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OpenTrials
Completed

NCT Number: NCT03429114

Emotion Regulation in Binge Eating and Purging Among Adolescents

The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

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Key information

Conditions

Binge Eating Bulimia Feeding and Eating Disorders Hyperphagia Mental Disorders Pathological Conditions, Signs and Symptoms Purging (Eating Disorders) Signs and Symptoms Signs and Symptoms, Digestive

Age range

14 year–18 year

Sex eligibility

Female

Study type

Observational

Primary location

Stanford University, Department of Psychiatry

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female
  • Ages 14-18
  • with or without current binge eating and/or purging behaviors

Exclusion criteria

We exclude patients of clinically significant low weight (<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.

Treatment and study plan

Magnetic Resonance Imaging

Other

We will conduct MRI and fMRI brain scans to compare brain function between groups.

Primary outcomes

  1. Brain activity during emotion conflict

    Time frame: Baseline

    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.

  2. Brain activity during emotion regulation

    Time frame: Baseline

    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.

  3. Brain activity during cognitive control and emotion response

    Time frame: Baseline

    Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.

Secondary outcomes

  1. Behavioral performance on emotion conflict task

    Time frame: Baseline

    Response times will be used as behavioral measure on the emotion conflict task

  2. Behavioral performance on emotion regulation task

    Time frame: Baseline

    Emotion ratings will be used as behavioral measure on the emotion regulation task

  3. Behavioral performance on cognitive control and emotion regulation task

    Time frame: Baseline

    Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Neural Correlates of Emotion Regulation and Executive Function in Binge Eating and Purging Among Adolescents

Important dates

Study start
2017
Primary completion
2022
Study completion
2022
First posted
Feb 12, 2018
Registry last updated
Dec 6, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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