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Completed

NCT Number: NCT05671068

EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)

Background:

Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.

Objective:

To investigate the neural correlates of cognition and emotion in DYT-SGCE.

Design:

Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.

Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.

Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.

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Key information

Conditions

Myoclonus-Dystonia DYT11 Myoclonic dystonia

Age range

15 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Brain Institute

Paris, 75013, France

About this study

Eligibility:

DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For all participants:

  • Age between 15-60 years
  • Able to give informed consent.

For patients:

  • An established diagnostic of DYT-SGCE
  • No change in medication (related to DYT-SGCE) for a month

For controls:

  • No neurological symptoms
  • No medication except oral contraception

Exclusion criteria

  • No deprivation of liberty
  • Inability to give a consent
  • Established cognitive alteration
  • Contraindication to MRI (per MRI safety checklist)
  • Severe chronic psychiatric illness

Treatment and study plan

Primary outcomes

  1. BOLD signal derived from the functional magnetic resonance imaging

    Time frame: 46 month

    Explore the differences in DYT-SGCE compared to HV

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Collaborators

  • Assistance Publique - Hôpitaux de Paris

Registry information

Official study title

CEREBELLAR INVOLVEMENT IN MOTOR, COGNITIVE AND EMOTIONAL PROCESSES IN MYOCLONUS DYSTONIA

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 4, 2023
Registry last updated
Jan 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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