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Enrolling by Invitation

NCT Number: NCT07525323

EMG ss AMG In Robotic/Laparoscopic Surgery

The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.

Enrolling by Invitation

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Key information

Conditions

Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Florida

Jacksonville, Florida, 32224, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > or = 18 years old
  • Patients willing to participate and provide an integrated, informed consent
  • Patients undergoing elective laparoscopic- or robotic-assisted surgical procedures
  • Anticipated surgery duration < 300 minutes Exclusion Criteria
  • Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
  • Patients with systemic neuromuscular diseases such as myasthenia gravis.
  • Patients having surgery that would involve prepping the arm into the sterile field.
  • Patients with chronic kidney disease (eGFR <60).

Treatment and study plan

AMG device

Device

The anesthesia team will use an AMG device to monitor neuromuscular block

EMG

Device

The anesthesia team will use an EMG device to monitor neuromuscular block

Primary outcomes

  1. Cumulative rocuronium dose

    Time frame: Perioperative/Periprocedural

    Weight- and time-adjusted mean cumulative rocuronium dose between the AMG and EMG groups

Secondary outcomes

  1. Mean sugammadex dose

    Time frame: Perioperative/Periprocedural

    Mean sugammadex dose between the two groups

  2. Number of rocuronium administrations

    Time frame: Perioperative/Periprocedural

    Number of rocuronium administrations throughout the case,

  3. Frequency of placing a peripheral nerve stimulator

    Time frame: Perioperative/Periprocedural

    Frequency of placing a peripheral nerve stimulator

  4. Depth of neuromuscular block prior to sugammadex administration

    Time frame: Perioperative/Periprocedural

    Depth of neuromuscular block prior to sugammadex administration

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

The Impact Of Electromyography Vs Acceleromyography On The Management Of Neuromuscular Block During Robotic And Laparoscopic Surgery: A Randomized Controlled Trial

Acronym: PEARL

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 13, 2026
Registry last updated
Jul 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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